CAJ | 학술논문

肺是心房利钠肽(ANP)的重要来源并拥有着完善的利钠肽调节系统.许多免疫器官能够检测出 ANP,多种免疫细胞表达利钠肽家族的受体,提示ANP具有免疫调节作用.既往对利钠肽和支气管哮喘(简称哮喘)的研究主要集中在其舒张支气管、减轻气道高反应性方面,但目前研究发现利钠肽系统可能在哮喘免疫、炎症等方面也起着关键作用,并可能参与了哮喘的发病及防御.
폐시심방리납태(ANP)적중요래원병옹유착완선적리납태조절계통.허다면역기관능구검측출 ANP,다충면역세포표체리납태가족적수체,제시ANP구유면역조절작용.기왕대리납태화지기관효천(간칭효천)적연구주요집중재기서장지기관、감경기도고반응성방면,단목전연구발현리납태계통가능재효천면역、염증등방면야기착관건작용,병가능삼여료효천적발병급방어.
The lung,having a perfect ANP regulatory system,is a significant source of ANP. The ANP can be detectable in some immune organs,and the receptors for NP are expressed in various immune cells,suggesting an effect of ANP in immunomodulation. Previous studies on ANP and asthma mainly focus on the bronchodilatory properties and reducing airway hyperreactivity. However, recent reports suggest that NP system may play a significant role in the immunity and inflammation of asthma and are important players in both the pathogenesis of and protection against asthma.