CAJ | 학술논문

目的观察不同剂量盐酸戊乙奎醚(长托宁)对内毒素休克兔回肠黏膜形态学的影响.方法 35只健康新西兰大白兔随机分成正常对照组、休克组、长托宁低剂量组(0.05 mg/kg)、长托宁中剂量组(0.15 mg/kg)和长托宁高剂量组(0.45 mg/kg).采用静脉注射大肠杆菌脂多糖(LPS)制作内毒素休克模型.长托宁各组分别于静注脂多糖后立即静注不同剂量长托宁.各组于静注后LPS6 h留取回肠标本进行形态学观察及回肠上皮损伤指数测定.结果长托宁低、中、高剂量组动物回肠黏膜损伤不同程度较休克组减轻(P<0.01),中剂量组损伤减轻更明显(P<0.01).结论长托宁能减轻内毒素休克兔的回肠黏膜损伤程度;相对于低、高剂量长托宁,中剂量在减轻组织损伤方面效果更为显著.
목적 관찰불동제량염산무을규미(장탁저)대내독소휴극토회장점막형태학적영향.방법 35지건강신서란대백토수궤분성정상대조조、휴극조、장탁저저제량조(0.05 mg/kg)、장탁저중제량조(0.15 mg/kg)화장탁저고제량조(0.45 mg/kg).채용정맥주사대장간균지다당(LPS)제작내독소휴극모형.장탁저각조분별우정주지다당후립즉정주불동제량장탁저.각조우정주후LPS6 h류취회장표본진행형태학관찰급회장상피손상지수측정.결과 장탁저저、중、고제량조동물회장점막손상불동정도교휴극조감경(P<0.01),중제량조손상감경경명현(P<0.01).결론 장탁저능감경내독소휴극토적회장점막손상정도;상대우저、고제량장탁저,중제량재감경조직손상방면효과경위현저.
Objective To observe the effect of different doses of Penehyclidine Hydrochloride(PQN) on intestinal mucosal morphology in the rabbit model of endotoxin shock. Methods Thirty-five healthy White New Zealand rabbits were randomly divided into five groups: control group, shock group, low dose PQN group (0.05 mg/kg), middle dose PQN group (0.15 mg/kg) and high dose PQN group (0.45 mg/kg). The endotoxin shock model was set up by the intravenous infusion with Lipopolysaccharide (LPS). Coincident with the injection of LPS, the different doses of PQN were immediately administered in the low, middle, high dose PQN group, respectively. The intestinal mucosal damage index and morphological changes of intestinal mucosa were observed and assayed under optics microscope and electric microscope at 6 hours after the injection of LPS. The differences among groups were statistically analyzed. Results Compared with the shock group, the intestinal mucosal damage of all PQN treat-ment groups were lessened (P<0.01), even more so in the middle dose PQN group (P<0.01).Conclusions Penehyclidine hydrochloride could relieve the intestinal mucosal damage in the rabbit model of endotoxin shock. Compared with the low and high dose, of PQN, the middle dose of PQN has better protective effect in the rabbit model of endotoxin shock.