CAJ | 학술논문

目的采用切伦科夫发光断层成像(CLT)和γ显像进行裸鼠甲状腺摄取131I的多模态成像,探索CLT与γ显像之间的相关性.方法先对4只裸鼠[体质量(21±3)g]尾静脉注射1.67×107 Bq 131I,在注药后0.5、3、12及24h均分别行CLT和γ显像.采用基于漫射方程(DE)的切伦科夫光源重建方法重建裸鼠体内131I的生物分布及在不同采集时间点甲状腺摄取131I的切伦科夫光的功率.对采集的γ显像图像勾画ROI,获得γ计数的平均值,对CLT 1311的切伦科夫光的功率和γ显像获取的γ计数行直线相关分析.结果甲状腺摄取131I的切伦科夫光的功率在0.5、3、12和24h分别为7.80×10-3、1.62×10-12、2.20×10 - 12和2.68×10-12 W.甲状腺摄取131I的切伦科夫光的功率随放射性药物注射时间的延长而逐渐增加.γ显像结果表明131I在裸鼠腹部的摄取逐渐降低,而在甲状腺的摄取越来越高,CLT与γ显像结果具有较好的相关性(r2 =0.7620,P＜O.05).结论 CLT具有临床甲状腺成像、甲状腺疾病诊断和疗效判断的潜力.
목적 채용절륜과부발광단층성상(CLT)화γ현상진행라서갑상선섭취131I적다모태성상,탐색CLT여γ현상지간적상관성.방법 선대4지라서[체질량(21±3)g]미정맥주사1.67×107 Bq 131I,재주약후0.5、3、12급24h균분별행CLT화γ현상.채용기우만사방정(DE)적절륜과부광원중건방법중건라서체내131I적생물분포급재불동채집시간점갑상선섭취131I적절륜과부광적공솔.대채집적γ현상도상구화ROI,획득γ계수적평균치,대CLT 1311적절륜과부광적공솔화γ현상획취적γ계수행직선상관분석.결과 갑상선섭취131I적절륜과부광적공솔재0.5、3、12화24h분별위7.80×10-3、1.62×10-12、2.20×10 - 12화2.68×10-12 W.갑상선섭취131I적절륜과부광적공솔수방사성약물주사시간적연장이축점증가.γ현상결과표명131I재라서복부적섭취축점강저,이재갑상선적섭취월래월고,CLT여γ현상결과구유교호적상관성(r2 =0.7620,P＜O.05).결론 CLT구유림상갑상선성상、갑상선질병진단화료효판단적잠력.
Objective To perform the multimodality 131I thyroid imaging using Cerenkov luminescence tomography (CLT) and gamma imaging,and to compare the results of CLT and gamma imaging.Methods The nude mice (n=4,mass:(21 ±3) g) were injected with 1.67 ×107 Bq 131I.CLT and gamma imaging were acquired at 0.5,3,12 and 24 h after the injection.Three-dimensional biodistribution of 131 I uptake in thyroid was reconstructed using Cerenkov source reconstruction method based on the diffusion equation ( DE),and the reconstructed power of 131I in different acquisition time points was obtained.Additionally,the ROIs were drawn over the gamma images of the mouse neck,and the counts were read.The correlation between the reconstructed power of CLT and gamma ray counts of gamma imaging was analyzed.Results The power of 131I uptake in thyroid at 0.5,3,12 and 24 h were 7.80 ×10-13,1.62×10-12,2.20×10-12 and 2.68 × 10-12 W,respectively.CLT results showed that reconstructed power increased with the increasing of acquisition time.Gamma imaging results indicated that 131I uptake decreased in abdomen and increased in thyroid with the collection time.The results of CLT were consistent with that of gamma imaging (r2 =0.7620,P ＜ 0.05 ).Conclusion CLT has the potential to identify and monitor functioning thyroid tissue at before and (or) after 131I treatment.