CAJ | 학술논문

目的探讨Vogt-小柳-原田综合征的临床及神经影像学特点。方法回顾我院收治的5例Vogt-小柳-原田综合征患者，总结其临床、脑脊液细胞学、神经影像学特点及药物治疗的效果。结果 5例患者均在发病早期确诊葡萄膜炎，并出现头痛症状，3例出现脑膜刺激征，所有患者颅脑MRI强化扫描均显示软脑膜较均匀强化。脑脊液白细胞计数均增高[(4 - 196)×106/L]。5例患者经大剂量激素联合环磷酰胺治疗均得到有效控制。结论假性脑膜炎是Vogt -小柳-原田综合征最常见的中枢神经系统表现，脑脊液细胞学检查主要表现为白细胞计数增高，颅脑MRI平扫及强化对该病的诊断具有一定价值。大剂量激素联合环磷酰胺治疗疗效确切。
목적 탐토Vogt-소류-원전종합정적림상급신경영상학특점。방법 회고아원수치적5례Vogt-소류-원전종합정환자，총결기림상、뇌척액세포학、신경영상학특점급약물치료적효과。결과 5례환자균재발병조기학진포도막염，병출현두통증상，3례출현뇌막자격정，소유환자로뇌MRI강화소묘균현시연뇌막교균균강화。뇌척액백세포계수균증고[(4 - 196)×106/L]。5례환자경대제량격소연합배린선알치료균득도유효공제。결론 가성뇌막염시Vogt -소류-원전종합정최상견적중추신경계통표현，뇌척액세포학검사주요표현위백세포계수증고，로뇌MRI평소급강화대해병적진단구유일정개치。대제량격소연합배린선알치료료효학절。
Objective To investigate the clinical and neuroimaging features of Vogt-KoyanagiHarada syndrome ( VKH ). Methods Cerebrospinal fluid ( CSF ), neuroimaging examination, clinical manifestation and pharmacotherapy features were investigated in 5 patients diagnosed as VKH. Results All 5 patients were diagnosed as uveitis in the early stage of disease. All patients suffered “ headache”.Meningeal irritation sign was appeared in 3 cases. The MRI enhanced scan of all 5 cases showed abnormal enhancement of meninges. CSF examination showed increased leukocyte number ((4--196) × 106/L). All patients were alleviated with combination therapy of high dose of steroid with cyclophosphamide.Conclusions VKH is a systemic disease that usually involving the uvea, central nervous system, internal ear and the skin. MRI and CSF examination are valuable for diagnosis. High dose of steroid combined with cyclophosphamide is an effective therapeutic strategy.