CAJ | 학술논문

目的　研究吡啶-2，6（1H，3H）二酮生物碱（SH1）对二磷酸腺苷（ADP），花生四烯酸（AA）和胶原（COL）诱导兔血小板聚集和TXB2和6-keto-PGF1α生成的影响. 方法　用比浊法和放射免疫法. 结果　SH1 0.8～3.0 mmol.L-1能显著地抑制2.0 μmol.L -1 ADP， 33.3 μmol.L-1 AA和20.0 g.L-1 COL诱导的兔血小板聚集并有良好的量效关系. SH1 3.0 mmol.L-1抑制TXB2产生，而增加6-keto-PGF1α 产生，并因此6-keto-PGF1α和TXB2的比值增加. 结论　SH 1显著抑制血小板聚集和TXB2产生，同时增加6-keto-PGF1α产生.
목적　연구필정-2，6（1H，3H）이동생물감（SH1）대이린산선감（ADP），화생사희산（AA）화효원（COL）유도토혈소판취집화TXB2화6-keto-PGF1α생성적영향. 방법　용비탁법화방사 면역법. 결과　SH1 0.8～3.0 mmol.L-1능현저지억제2.0 μmol.L -1 ADP， 33.3 μmol.L-1 AA화20.0 g.L-1 COL유도적토혈소판취집병유량호적량효관계. SH1 3.0 mmol.L-1억제TXB2산생，이증가6-keto-PGF1α 산생，병인차6-keto-PGF1α화TXB2적비치증가. 결론　SH 1현저억제혈소판취집화TXB2산생，동시증가6-keto-PGF1α산생.
AIM　To investigate the effect of pyridine-2,6（1H,3H）-dion e alkaloids （SH1） on rabbit platelet aggrega-tion induced by adenosine diphosphate （ADP）, arachidonic acid （AA） and collagen （COL）, as well as thromboxone B2 （TXB2） and 6-keto-PGF1α production. METHODS　Turbidimetry and radioimmunoassay were used in rabbits. RESULTS　SH2 0.8～3.0 mmol.L-1 could inhibit significantly th e rabbit platelet aggregation induced by ADP 2 μmol.L-1, AA 33.3 μmol.L-1, COL 20. 0 mg.mL-1, which showed good dose-dependence. The inhibition by SH1 0. 8～3.0 mmol.L-1was 23.3%～53.2% （ADP-induced）, 13.3～44.4 （AA-induced）, 5.1%～49.3% （COL-induced）, respectively. SH2 0.8～3.0 mmol.L-1 inhibited TXB2 production, whereas increased 6-keto-PGF1α to TXB2 was enhanced. CONCLUSION　SH1 inhibits significantly platelet aggregation and TXB2 production, and simultane ously increases 6-keto-PGF1α.