CAJ | 학술논문

目的探讨甲状腺球蛋白抗体(TGAb)和甲状腺微粒体抗体(TMAb)定量检测在自身免疫性甲状腺炎诊断中的应用.方法对219例甲状腺肿大患者和500例正常血清用酶免疫法(EIA)定量检测甲状腺球蛋白抗体和甲状腺微粒体抗体.结果甲状腺肿大患者TGAb和TMAb定量检测结果分别为(295±648)IU/mL和(309±536)IU/mL,检出率分别为61%(134/219)和62%(136/219),经过2种抗体的检测,最后有126例确诊为自身免疫性甲状腺炎(AITT).500例健康对照TGAb和TMAb定量检测分别为(9±4)IU/mL和(14±6)IU/mL.结论 EIA定量检测血清TGAb和TMAb操作简便,结果准确,符合临床常规使用要求,对自身免疫性甲状腺炎的诊断、疗效观察具有重要临床应用价值.
목적 탐토갑상선구단백항체(TGAb)화갑상선미립체항체(TMAb)정량검측재자신면역성갑상선염진단중적응용.방법 대219례갑상선종대환자화500례정상혈청용매면역법(EIA)정량검측갑상선구단백항체화갑상선미립체항체.결과 갑상선종대환자TGAb화TMAb정량검측결과분별위(295±648)IU/mL화(309±536)IU/mL,검출솔분별위61%(134/219)화62%(136/219),경과2충항체적검측,최후유126례학진위자신면역성갑상선염(AITT).500례건강대조TGAb화TMAb정량검측분별위(9±4)IU/mL화(14±6)IU/mL.결론 EIA정량검측혈청TGAb화TMAb조작간편,결과준학,부합림상상규사용요구,대자신면역성갑상선염적진단、료효관찰구유중요림상응용개치.
Objective To explore the clinical application of thyroglobulin antibody (TGAb) and thyroid microsomal antibody (TMAb) quantitive determination with enzyme immunoassay (EIA) in the diagnosis of autoimmune thyroiditis.Methods EIA was applied to quantitively determining serum TGAb and TMAb in 219 patients with thyromegaly (thyromegaly group) and 500 healthy controls (healthy control group).Results The serum level of TGAb and TMAb in thyromegaly group was (295±648) IU/mL ［detection rate: 61%(134/219)］ and (309±536)IU/mL ［detection rate: 62% (136/219)］, respectively. Eventually, 126 cases were definitely diagnosed as autoimmune thyroiditis (AITT) through the determination of the two antibodies. The serum level of TGAb and TMAb in healthy control group was (9±4) IU/mL and (14±6) IU/mL respectively.Conclusion TGAb and TMAb quantitive determination with EIA is convenient and accurate, in accordance with clinical requirement, contributing to diagnosis and therapeutic effect evaluation of autoimmune thyroiditis.