CAJ | 학술논문

目的比较吡格列酮和瑞舒伐他汀对兔血脂紊乱的作用.方法 40只白兔随机分为空白对照组、血脂紊乱组、瑞舒伐他汀组、吡格列酮组,除空白对照组外,其余3组高脂饮食.8 w后,瑞舒伐他汀组、吡格列酮组开始用药,用药量分别为瑞舒伐他汀1.5 mg·kg~(-1)·d~(-1),吡格列酮5 mg·kg~(-1)·d~(-1),用药6 w.取血,检测血脂、血糖、TNF-α等指标.结果吡格列酮组和瑞舒伐他汀组总胆固醇低于血脂紊乱组(P＜0.05).吡格列酮组TG最低,但与各组比较无统计学差异(P＞0.05).ApoA在瑞舒伐他汀组和吡格列酮组均增高,吡格列酮组高于血脂紊乱组(P＜0.05).瑞舒伐他汀组LDL-C较血脂紊乱组降低40%,与血脂紊乱组和吡格列酮组比较均降低(P＜0.05).二者TNF-α低于血脂紊乱组(P＜0.05).吡格列酮组进食量、血糖较血脂紊乱组减低(P＜0.05),瑞舒伐他汀可降低血糖,与吡格列酮组血糖水平接近(P＞0.05).结论二者均有降血糖、改善血脂、抗炎症的作用,但在降低甘油三酯的作用上吡格列酮较瑞舒伐他汀强,而瑞舒伐他汀降低低密度脂蛋白最强.
목적 비교필격렬동화서서벌타정대토혈지문란적작용.방법 40지백토수궤분위공백대조조、혈지문란조、서서벌타정조、필격렬동조,제공백대조조외,기여3조고지음식.8 w후,서서벌타정조、필격렬동조개시용약,용약량분별위서서벌타정1.5 mg·kg~(-1)·d~(-1),필격렬동5 mg·kg~(-1)·d~(-1),용약6 w.취혈,검측혈지、혈당、TNF-α등지표.결과 필격렬동조화서서벌타정조총담고순저우혈지문란조(P＜0.05).필격렬동조TG최저,단여각조비교무통계학차이(P＞0.05).ApoA재서서벌타정조화필격렬동조균증고,필격렬동조고우혈지문란조(P＜0.05).서서벌타정조LDL-C교혈지문란조강저40%,여혈지문란조화필격렬동조비교균강저(P＜0.05).이자TNF-α저우혈지문란조(P＜0.05).필격렬동조진식량、혈당교혈지문란조감저(P＜0.05),서서벌타정가강저혈당,여필격렬동조혈당수평접근(P＞0.05).결론 이자균유강혈당、개선혈지、항염증적작용,단재강저감유삼지적작용상필격렬동교서서벌타정강,이서서벌타정강저저밀도지단백최강.
Objective To assess the comparative efficacy of pioglitazone and rosuvastatin on dyslipidemia rabbits. Methods Forty rabbits were randomly divided into control, dyslipid, rosuvastatin and pioglitazone groups. Except control group, all rabbits were fed with high fat fodder. After 8 w, rosuvastatin (1.5 mg·kg~(-1)·d~(-1)) and pioglitazone(5 mg·kg~(-1)·d~(-1)) were administered to the rabbits of rosuvastatin and pioglitazone groups respectively for 6 w. Then the levels of lipids, glucose and TNF-α were determined. Results The levels of total cholesterol in pioglitazone and rosuvastatin groups were lower than those in dyslipid group (P＜0.05). The level of triglyceride in pioglitazone group was the lowest, but no significant difference compared to those of other groups(P＞0.05). The levels of apolipoprotein-A were increased in pioglitazone and rosuvastatin groups, the level of apo-A in pioglitazone group was higher than that in dyslipid group. The low density lipoprotein-C in rosuvastatin group was lower than those in pioglitazone and dyslipid groups(P＜0.05), and was decreased by 40% compared to that of dyslipid group. The levels of TNF-α in pioglitazone and rosuvastatin groups were lower than those in dyslipid group(P＜0.05).The intake and the level of glucose in pioglitazone group were lower than those in dyslipid group(P＜0.05). Rosuvastatin could decrease the level of glucose, which was almost the same level as pioglitazone(P＞0.05). Conclusions Pioglitazone and rosuvastatin have the effects in lowing glucose, improving lipids, anti-inflammation. Pioglitazone is better in decreasing the level of triglyceride compared to rosuvastatin. Rosuvastatin is the best in decreasing low density lipoprotein-C.