化学试剂
化學試劑
화학시제
CHEMICAL REAGENTS
2010年
1期
63-65,93
,共4页
异(噁)唑衍生物%酰基脲%合成%抑菌活性
異(噁)唑衍生物%酰基脲%閤成%抑菌活性
이(오)서연생물%선기뇨%합성%억균활성
isoxazole%acylurea%synthesis%antimicrmatic activity
以5-甲基-3-(取代)苯基-4-异(噁)唑甲酰胺及取代苯胺为起始原料,经两步反应合成了10种N-取代苯基-5-甲基-3-(取代)苯基-4-异(噁)唑甲酰基脲新化合物,其结构经 ~1HNMR 、IR和元素分析确证.初步测试了目标化合物对番茄灰霉病菌和小麦纹枯病菌的室内抑菌活性,结果表明,部分化合物对番茄灰霉病菌表现出较好的抑菌活性.
以5-甲基-3-(取代)苯基-4-異(噁)唑甲酰胺及取代苯胺為起始原料,經兩步反應閤成瞭10種N-取代苯基-5-甲基-3-(取代)苯基-4-異(噁)唑甲酰基脲新化閤物,其結構經 ~1HNMR 、IR和元素分析確證.初步測試瞭目標化閤物對番茄灰黴病菌和小麥紋枯病菌的室內抑菌活性,結果錶明,部分化閤物對番茄灰黴病菌錶現齣較好的抑菌活性.
이5-갑기-3-(취대)분기-4-이(오)서갑선알급취대분알위기시원료,경량보반응합성료10충N-취대분기-5-갑기-3-(취대)분기-4-이(오)서갑선기뇨신화합물,기결구경 ~1HNMR 、IR화원소분석학증.초보측시료목표화합물대번가회매병균화소맥문고병균적실내억균활성,결과표명,부분화합물대번가회매병균표현출교호적억균활성.
Ten novel compounds of N-substituted phenyl-5-methyl-3-(substituted) phenyl-4-isoxazolyl acylureas derivatives were synthesized with 5-methyl-3-(substituted) phenyl-4-isoxazolyl acylamide and substituted anilines as starting materials,which were characterized by means of IR,~1HNMR spectra and elemental analysis.Preliminary antibacterial experiments were tested,and the results indicated that some of the above compounds have good antibacterial activities.
