CAJ | 학술논문

合成了大分子引发剂(CS-Br)--壳聚糖(CS)接枝2-溴丙酰溴,然后以溴化亚铜与五甲基二乙烯三胺(PMDETA)为催化体系,氯甲基化甲基丙烯酸二甲氨乙酯季铵盐(DMC)为单体,利用原子转移自由基聚合法制备了新材料P(CS-Br-DMC).重点研究了该材料对白色念珠菌、金黄色葡萄球菌和大肠杆菌的最低抑菌浓度(MIC)、抑菌圈直径及溶血性.同时考察了其在不同时间对三种菌种生长的影响,并且与壳聚糖本身的抑菌性进行了对比.结果表明,该材料比壳聚糖具有更好的水溶性和抑菌性,其对金黄色葡萄球菌的抑菌效果最佳.
합성료대분자인발제(CS-Br)--각취당(CS)접지2-추병선추,연후이추화아동여오갑기이을희삼알(PMDETA)위최화체계,록갑기화갑기병희산이갑안을지계안염(DMC)위단체,이용원자전이자유기취합법제비료신재료P(CS-Br-DMC).중점연구료해재료대백색념주균、금황색포도구균화대장간균적최저억균농도(MIC)、억균권직경급용혈성.동시고찰료기재불동시간대삼충균충생장적영향,병차여각취당본신적억균성진행료대비.결과표명,해재료비각취당구유경호적수용성화억균성,기대금황색포도구균적억균효과최가.
The maeroinitiator (CS-Br) was composed with chitosan (CS) and 2-bromopropionyl bromide. Then, with CS-Br as macroinitiator and CuBr/N, N, N', N', N" -pentamethyldiethylenetriamine (PMDETA) as a catalyst, a novel material P (CS-Br-DMC)was successfully prepared with CS-Br and chlorine methylation dimethyl ammonium ethyl methacrylate(DMC) via atom transfer radical polymerization (ATRP). The minimal inhibitory concentration (MIC), inhibition zone and hemolysis of Candida albicans, Staphylococcus aureus and Escherichia coli were focused on. Meanwhile, the antibacterial activity of the materials through the different time on the growth of three colonies were investigated. Furthermore, its water solubility and MIC was compared with CS. The findings indicated that the water solubility and antibacterial activity of new substance was better than that of CS especially for Staphylococcus aureus.