中华普通外科学文献（电子版）
中華普通外科學文獻（電子版）
중화보통외과학문헌（전자판）
CHINESE JOURNAL OF GENERAL SURGERY(ELECTRONIC VERSION)
2012年
5期
27-30
,共4页
苏春华%苏毅华%陈振光%罗红鹤%邹健勇%何裕隆
囌春華%囌毅華%陳振光%囉紅鶴%鄒健勇%何裕隆
소춘화%소의화%진진광%라홍학%추건용%하유륭
Notch1%食管鳞癌%无疾病进展期%总生存期
Notch1%食管鱗癌%無疾病進展期%總生存期
Notch1%식관린암%무질병진전기%총생존기
Notch1%Esophageal Squamous Cell Carcinoma%Progression-free survival%Overall survival
目的 了解单次跨膜受体蛋白Notch家族成员1表达异常是否为食管鳞癌术后早期复发转移的危险因素之一,为T3N0M0期患者术后早期辅助化疗的选择提供依据.方法 通过免疫组化方法检测40例T3N0M0期食管鳞癌患者和8例正常食管组织的Notch1的表达情况,将病例分为Notch1(+)组和Notch1(-)组,对两组患者性别、年龄和肿瘤分化程度进行方差分析,并追踪分析两组患者的无疾病进展期(PFS)和总生存期(0S).结果 Notch1在食管鳞癌组织中表达明显低于正常食管组织(P＜0.05),52.5％(21/40)病例中Notch1表达阴性,47.5％(19/40)病例中Notch1表达阳性.Notch1表达阳性组患者的PFS(月)较表达阴性组的PFS长,差异有统计学意义(16.63±7.38 vs.12.19±5.48,P＜0.05),但两组患者OS(月)比较无统计学差异(25.89±4.67vs.23.05±4.47,P=0.056).结论 肿瘤组织中Notch1阴性表达的患者术后容易复发转移,Notch1表达阴性可能是食管鳞癌术后早期复发转移的危险因素之一,有该危险因素的T3N0M0患者提示需要早期术后辅助化疗.
目的 瞭解單次跨膜受體蛋白Notch傢族成員1錶達異常是否為食管鱗癌術後早期複髮轉移的危險因素之一,為T3N0M0期患者術後早期輔助化療的選擇提供依據.方法 通過免疫組化方法檢測40例T3N0M0期食管鱗癌患者和8例正常食管組織的Notch1的錶達情況,將病例分為Notch1(+)組和Notch1(-)組,對兩組患者性彆、年齡和腫瘤分化程度進行方差分析,併追蹤分析兩組患者的無疾病進展期(PFS)和總生存期(0S).結果 Notch1在食管鱗癌組織中錶達明顯低于正常食管組織(P＜0.05),52.5％(21/40)病例中Notch1錶達陰性,47.5％(19/40)病例中Notch1錶達暘性.Notch1錶達暘性組患者的PFS(月)較錶達陰性組的PFS長,差異有統計學意義(16.63±7.38 vs.12.19±5.48,P＜0.05),但兩組患者OS(月)比較無統計學差異(25.89±4.67vs.23.05±4.47,P=0.056).結論 腫瘤組織中Notch1陰性錶達的患者術後容易複髮轉移,Notch1錶達陰性可能是食管鱗癌術後早期複髮轉移的危險因素之一,有該危險因素的T3N0M0患者提示需要早期術後輔助化療.
목적 료해단차과막수체단백Notch가족성원1표체이상시부위식관린암술후조기복발전이적위험인소지일,위T3N0M0기환자술후조기보조화료적선택제공의거.방법 통과면역조화방법검측40례T3N0M0기식관린암환자화8례정상식관조직적Notch1적표체정황,장병례분위Notch1(+)조화Notch1(-)조,대량조환자성별、년령화종류분화정도진행방차분석,병추종분석량조환자적무질병진전기(PFS)화총생존기(0S).결과 Notch1재식관린암조직중표체명현저우정상식관조직(P＜0.05),52.5％(21/40)병례중Notch1표체음성,47.5％(19/40)병례중Notch1표체양성.Notch1표체양성조환자적PFS(월)교표체음성조적PFS장,차이유통계학의의(16.63±7.38 vs.12.19±5.48,P＜0.05),단량조환자OS(월)비교무통계학차이(25.89±4.67vs.23.05±4.47,P=0.056).결론 종류조직중Notch1음성표체적환자술후용역복발전이,Notch1표체음성가능시식관린암술후조기복발전이적위험인소지일,유해위험인소적T3N0M0환자제시수요조기술후보조화료.
Objective To study the characteristic of Notch1 expressed in T3N0M0 ESCC and the relation with cancer relapse and metastasis. Methods Forty tissue slices of T3N0M0 ESCC and 8 cases normal esophagus tissues were acquired to analysis the expression of Notchl by immunohistochemistry.They were divided into two groups which were Notch1 (+) group and Notch1 (-) group.Patients' sex,ageand cancer cell differentiation were analyzed by ANOVA.Patiens' progression free survival (PFS) and overall survival (OS) were followed up.Results Notch1 expression was significantly lower in the cancer group than in the normal group (P ＜ 0.05).Notch1 expression was negative in 52.5％ (21/40) cases and positive in 47.5％ (19/40) cases.PFS (month) of Notch1 (+) group was longer than that of Notchl (-)group(16.63 ± 7.38 vs.12.19 ± 5.48,t =2.174,P =0.036).But two groups patiens' OS(month) had no statistical significance(25.89 ± 4.67 vs.23.05 ± 4.47,t =1.971,P =0.056).Conclusion Negative expression of Notch1 in cancer may be one of the predicted factors of early relapse and metastasis of ESCC in afteroperation.
