CAJ | 학술논문

骨髓间充质干细胞(BMSCs)是一种存在于人和动物骨髓等组织中,具备有多向分化潜能的成体干细胞体系.其具有取材简便、易于体外培养扩增、体内移植免疫排异反应少、可自体移植避免伦理学争议等众多优势.骨髓间充质干细胞在体外一系列不同的实验方案中,被诱导分化为神经细胞,这为神经系统受损伤后的修复和再生带来了新希望.结合近几年的研究进展,对骨髓间充质干细胞在体外培养条件下向神经细胞诱导分化的各种方案及其可能机制作一综述.
골수간충질간세포(BMSCs)시일충존재우인화동물골수등조직중,구비유다향분화잠능적성체간세포체계.기구유취재간편、역우체외배양확증、체내이식면역배이반응소、가자체이식피면윤리학쟁의등음다우세.골수간충질간세포재체외일계렬불동적실험방안중,피유도분화위신경세포,저위신경계통수손상후적수복화재생대래료신희망.결합근궤년적연구진전,대골수간충질간세포재체외배양조건하향신경세포유도분화적각충방안급기가능궤제작일종술.
Bone marrow-derived mesenchymal stem cells(BMSCs)exist in and can be isolated from the bone marrow of adult human being and animals and can be induced to differentiate into different cells.They are easy to be isolated,cultivated,and amplified.They are also less immunogenic in the body and can avoid ethical dispute when applied in transplantation.Studies have shown that BMSCs can be induced to differentiate into neural cells under certain conditions in vitro.This article reviewed the recent development in the research on the induction protocols for neural differentiation of BMSCs and the possible mechanisms.