CAJ | 학술논문

目的总结甲型H1N1流感患者的临床特征,分析奥司他韦疗效.方法回顾性收集了我院560例轻症甲型H1N1流感住院患者的临床资料,包括年龄、主要症状、实验室检查、发热至口服奥司他韦的时间、发热持续时间、病毒转阴时间;分析发热至口服奥司他韦的时间与发热持续时间及病毒转阴时间的相关性.患者按发热至口服奥司他韦的时间不同分三组,比较不同组间发热持续时间及病毒转阴时间是否有差异.结果大部分患者症状为发热(97.0%)及咳嗽(90.0%);少数伴有胃肠道(1.8%)或神经系统症状(0.9%);部分患者血常规及生化异常;16.6%的患者心电图呈非特异性改变.患者从发热到起始服奥司他韦时间与发热持续时间及病毒转阴时间均呈正相关(r=0.83,P＜0.01;r=0.60,P＜0.01).各组之间比较其发热持续时间及病毒转阴时间差异有统计学意义(P＜0.01).结论轻症甲型H1N1流感临床特征与季节性流感类似,发热患者早期口服奥司他韦治疗可能会缩短发热持续时间及病毒转阴时间.
목적 총결갑형H1N1류감환자적림상특정,분석오사타위료효.방법 회고성수집료아원560례경증갑형H1N1류감주원환자적림상자료,포괄년령、주요증상、실험실검사、발열지구복오사타위적시간、발열지속시간、병독전음시간;분석발열지구복오사타위적시간여발열지속시간급병독전음시간적상관성.환자안발열지구복오사타위적시간불동분삼조,비교불동조간발열지속시간급병독전음시간시부유차이.결과 대부분환자증상위발열(97.0%)급해수(90.0%);소수반유위장도(1.8%)혹신경계통증상(0.9%);부분환자혈상규급생화이상;16.6%적환자심전도정비특이성개변.환자종발열도기시복오사타위시간여발열지속시간급병독전음시간균정정상관(r=0.83,P＜0.01;r=0.60,P＜0.01).각조지간비교기발열지속시간급병독전음시간차이유통계학의의(P＜0.01).결론 경증갑형H1N1류감림상특정여계절성류감유사,발열환자조기구복오사타위치료가능회축단발열지속시간급병독전음시간.
Objective To summarize the clinical features of influenza A(H1N1) and analyze the efficacy of oseltamivir. Methods The clinical data of 560 hospitalized patients with influenza A(H1N1) were collected retrospectively,included their ages, major symptoms, test results, the times from heat to oseltamivir treatment, heating duration and the virus clearance times, to analyze the correlation between the times from heat to oseltamivir treatment and heating duration or the virus clearance times. According to times from heat to oseltamivir treatment, patients were divided into 3 groups,compared the differences of median heating duration and the virus clearance time. Results Most patients had fever (97.0%)and cough(90.0%). A few patients had symptoms of gastrointestinal(1.8%) or nervous system(0.9%);some patients had biochemical abnormalities; ECG showed non-specific changes in 16.6% patients. There was a positive correlation between the time from heat to oseltamivir treatment and heating duration or the virus clearance time(r=0.83,P＜0.01;r=0.60,P＜0.01). There were also statistical differences in heating duration and the virus clearance time of different groups(P＜0.01). Conclusions The clinical features of patients with influenza A(H1N1) are similar to the features of seasonal influenza. Early oseltamivir treatment for patients with fever may reduce the heating duration and the virus clearance time.