CAJ | 학술논문

恶性肿瘤严重地威胁着人类的健康.多药耐药现象增加了其治疗难度,局部复发和远处转移最终导致了治疗失败,然而遗憾的是机制尚不清楚.研究发现在肿瘤组织中有一个具有自我更新及分化潜能的的细胞亚群,是复发及转移的根源.这部分细胞被称为肿瘤干细胞.随后,人们相继从血液系统肿瘤及多种实体瘤中分离、鉴定了肿瘤干细胞.随着肿瘤干细胞学说的提出及确认,人们对肿瘤的复发、转移及多药耐药现象有了新的认识,从而为恶性肿瘤的治疗及复发转移的预防提供了一个全新的线索.本文就此进行综述.
악성종류엄중지위협착인류적건강.다약내약현상증가료기치료난도,국부복발화원처전이최종도치료치료실패,연이유감적시궤제상불청초.연구발현재종류조직중유일개구유자아경신급분화잠능적적세포아군,시복발급전이적근원.저부분세포피칭위종류간세포.수후,인문상계종혈액계통종류급다충실체류중분리、감정료종류간세포.수착종류간세포학설적제출급학인,인문대종류적복발、전이급다약내약현상유료신적인식,종이위악성종류적치료급복발전이적예방제공료일개전신적선색.본문취차진행종술.
Malignant tumors still threatens the human's health seriously. Metastasis and recurrence lead to the failure of treatment, and multidrug resistance adds the difficulty of therapy of to malignant tumors. But the mechanism is yet unclear. Nowadays, it is found that there's a small group of cells with selfrenewal and indefinite potency in the tumors, and they are the sources of metastasis and recurrence. This small group of cells is called cancer stem cells. Subsequently, the cancer stem ceils were separated and determined from hematological system tumor and solid tumor respectively. The cognitions for metastasis and recurrence and muhidrug resistance of malignant tumor have changed with proposal and verification of the cancer stem cell theory, which provides a new clue to the treatment of tumor and prevention for the metastasis and recurrence.