CAJ | 학술논문

目的探讨复方丹参滴丸对氯比格雷抵抗患者的干预效果.方法采用比浊法测定血小板聚集率,将氯比格雷抵抗患者58例随机分为两组,氯比格雷+复方丹参滴丸组及单服氯吡格雷组,每组29例.干预2周后分别复查血小板聚集率.结果干预后氯吡格雷+复方丹参滴丸组二磷酸腺甘(ADP)诱导的血小板聚集率为28.25%,较干预前的37.78％下降9.53%(P<0.01);而单用氯吡格雷组十预前后无明显变化(P>0.05).结论复方丹参滴丸可以增强患者对氯比格雷的敏感性,减轻氯比格雷抵抗,两药有协同抗血小板作用.
목적 탐토복방단삼적환대록비격뢰저항환자적간예효과.방법 채용비탁법측정혈소판취집솔,장록비격뢰저항환자58례수궤분위량조,록비격뢰+복방단삼적환조급단복록필격뢰조,매조29례.간예2주후분별복사혈소판취집솔.결과 간예후록필격뢰+복방단삼적환조이린산선감(ADP)유도적혈소판취집솔위28.25%,교간예전적37.78％하강9.53%(P<0.01);이단용록필격뢰조십예전후무명현변화(P>0.05).결론 복방단삼적환가이증강환자대록비격뢰적민감성,감경록비격뢰저항,량약유협동항혈소판작용.
Objectives To investigate the effects of compound danshen drop pill on clopidogrel resistance. Methods Fifty eight patients with clopidogrel resistance were selected according to platelet aggregation from 232 inpatients who had taken clopidogrel75mg for 24 hours.They were randomized to two groups: compound danshen drop pill plus clopidogrel,clopidogrel only. Platelet aggregation was evaluated later two weeks after interference(P＞ 0.05 ). Results Adenosine diphosphate(ADP) induced platelet aggregation of the grop compound danshen drop pill plus clopidogrel decreased 9.53%(P＜0.01 ),while there was no significant change in clopidogrel only group. Conclusion Compound danshen drop pill improve platelet sensitivity to clopidogrel,and has synergistic anti-platelet effects,thus could be administered to interfere clopidogrel resistance effectively.