CAJ | 학술논문

呼吸道合胞病毒(respiratory syncytial virus,RSV)是婴幼儿呼吸道感染最常见的病原,但发病机制尚未明了.近年研究发现,肺表面活性蛋白介导的天然免疫应答在RSV感染中发挥重要作用,而调控这些蛋白表达的基因存在多态性.因此,研究肺表面活性蛋白及其基因多态性在RSV感染发病中的作用,将为开发新的RSV感染治疗方法提供理论依据.
호흡도합포병독(respiratory syncytial virus,RSV)시영유인호흡도감염최상견적병원,단발병궤제상미명료.근년연구발현,폐표면활성단백개도적천연면역응답재RSV감염중발휘중요작용,이조공저사단백표체적기인존재다태성.인차,연구폐표면활성단백급기기인다태성재RSV감염발병중적작용,장위개발신적RSV감염치료방법제공이론의거.
Respiratory syncytial virus (RSV) is the most common pathogen of respiratory tract infection in infants and children, but the pathogenesis is still unclear. Recently, studies have found that innate immune response mediated by surfactant protein plays an important role in RSV infection, and regulation genes of these proteins are polymorphic. Therefore,the study of roles of surfactant protein and its gene polymorphism in pathogenesis of RSV infection may provide a theoretical basis for new treatment of RSV infection.