CAJ | 학술논문

肺癌是世界范围内死亡率最高的恶性肿瘤之一，也是我国常见的恶性肿瘤之一，恶性程度高，发展迅速，治疗困难，总体疗效不理想。肿瘤干细胞是肿瘤组织中一小部分具有自我更新、无限增殖和多向分化能力的肿瘤细胞，它在肿瘤组织中所占比例虽然很少，却与肿瘤起源、发展与转移关系密切，因此肿瘤干细胞被看作是一个根除癌症的潜在目标。CD133是在人类造血干细胞中发现的一种跨膜糖蛋白，并认为是多种干细胞的表面标志之一，并且CD133+细胞与肿瘤的转移、肿瘤的血管生成都有关系。另外研究者报道，可通过检测CD133 mRNA水平预测肿瘤的复发，并且认为可以作为某些肿瘤的预后指标。因此，有人认为CD133可能是肺癌干细胞的肿瘤标记物。本文就CD133在肺癌中的研究加以综述。
폐암시세계범위내사망솔최고적악성종류지일，야시아국상견적악성종류지일，악성정도고，발전신속，치료곤난，총체료효불이상。종류간세포시종류조직중일소부분구유자아경신、무한증식화다향분화능력적종류세포，타재종류조직중소점비례수연흔소，각여종류기원、발전여전이관계밀절，인차종류간세포피간작시일개근제암증적잠재목표。CD133시재인류조혈간세포중발현적일충과막당단백，병인위시다충간세포적표면표지지일，병차CD133+세포여종류적전이、종류적혈관생성도유관계。령외연구자보도，가통과검측CD133 mRNA수평예측종류적복발，병차인위가이작위모사종류적예후지표。인차，유인인위CD133가능시폐암간세포적종류표기물。본문취CD133재폐암중적연구가이종술。
Lung carcinoma is one of the most common cause of cancer-related death in the world,and is also one of the most common malignant tumors in China. It is difficult to cure because of its high-grade malignancy and rapid progress. Cancer stem cells (CSC) is a small part of tumor cells with self-renewal, unlimited proliferation and multi-differentiation capacity in tumor tissue. While CSC has small proportion in the tumor tissue, it is closely related with tumor origin, development and metastasis, and thus considered as a potential target to eradicate tumors. CD133 is a transmembrane glycoprotein found in human hematopoietic stem cells, which is thought as a surface marker of several stem cells. CD133+ cells are associated with tumor metastasis and tumor microvessels formation. Tumor relapse could be detected by quantitative CD133 mRNA expression. CD133 is also the biomarker of CSC of lung cancer. So this paper reviews CD133 and the related research in lung cancer.