CAJ | 학술논문

脂联素与脂联素受体结合,经多种信号转导途径发挥改善胰岛素抵抗、调节糖脂代谢、负性调控炎性反应以及拮抗动脉粥样硬化的作用.一些病理牛理过程中脂联素水平升高,但没有显著保护性效应,提示存在脂联素抵抗.脂联素抵抗的机制包括脂联素聚合能力改变、脂联素受体(AdipoRs)表达减少及脂联素受体后AMP活化蛋白激酶(AMPK)、过氧化物酶体增殖物活化受体(PPAR)α等信号通路转导障碍.高血糖、肥胖、胰岛素抵抗等与脂联素抵抗密切相关,可以互为因果,形成恶性循环.
지련소여지련소수체결합,경다충신호전도도경발휘개선이도소저항、조절당지대사、부성조공염성반응이급길항동맥죽양경화적작용.일사병리우리과정중지련소수평승고,단몰유현저보호성효응,제시존재지련소저항.지련소저항적궤제포괄지련소취합능력개변、지련소수체(AdipoRs)표체감소급지련소수체후AMP활화단백격매(AMPK)、과양화물매체증식물활화수체(PPAR)α등신호통로전도장애.고혈당、비반、이도소저항등여지련소저항밀절상관,가이호위인과,형성악성순배.
Adiponectin call improve insulin sensitivity,shcose and lipid metabolism and exert antiinflammatory and antiatherogenic effects by binding to its receptors,leading to activation of some signaling pathways.Hyperadiponectinaemia is found in some pathophysiological processes,without significant protective effect,which indicates the existence of adiponectin resistance.Mechanism of adiponectin resistance may include impaired multimerization of adiponectin mutants.down regulation of adiponectin receptors(AdipoRs) expression and deterioration of postreceptor signaling via AMP activated protein kinase(AMPK)and peroxisome proliferator activated receptor(PPAR) α activation.Hyperglycemia,obesity,and insulin resistance are closely related to adiponectin resistance.They may be a reciprocal causation and form a vicious circle.