中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
10期
70-71
,共2页
纳洛酮%长托宁%重度有机磷农药中毒
納洛酮%長託寧%重度有機燐農藥中毒
납락동%장탁저%중도유궤린농약중독
Naloxone%Penehyclidine hydrochloride%Severe organophosphorus pesticide poisoning
目的 探讨纳洛酮联合长托宁在中、重度有机磷农药中毒的治疗中的作用及临床应用.方法 将60例患者随机分为联合组、长托宁组和对照组,每组20例.联合组在对照组基础上加用纳洛酮,同时将阿托品改为长托宁;对照组采用传统方法,以阿托品联合氯磷定治疗为主;长托宁组以长托宁代替阿托品,同时运用氯解磷定等药物.纳洛酮首剂静脉注射1.2 mg,随后静脉滴注1.6 mg,连用5d.长托宁首剂4 mg,肌肉注射,根据病情加量至阿托品化,并维持阿托品化.结果 联合组总有效率(90.00％)高于长托宁组(75.00％)及对照组(50.00％),差异有统计学意义(P＜0.05);在给药次数、住院天数方面,联合组明显少于对照组,差异有统计学意义(P＜0.01).结论 纳洛酮联合长托宁治疗中、重度有机磷农药中毒,相对于单用长托宁或不使用长托宁的常规治疗,能显著提高治愈率,降低病死率,无疑为一种有效的治疗方法.
目的 探討納洛酮聯閤長託寧在中、重度有機燐農藥中毒的治療中的作用及臨床應用.方法 將60例患者隨機分為聯閤組、長託寧組和對照組,每組20例.聯閤組在對照組基礎上加用納洛酮,同時將阿託品改為長託寧;對照組採用傳統方法,以阿託品聯閤氯燐定治療為主;長託寧組以長託寧代替阿託品,同時運用氯解燐定等藥物.納洛酮首劑靜脈註射1.2 mg,隨後靜脈滴註1.6 mg,連用5d.長託寧首劑4 mg,肌肉註射,根據病情加量至阿託品化,併維持阿託品化.結果 聯閤組總有效率(90.00％)高于長託寧組(75.00％)及對照組(50.00％),差異有統計學意義(P＜0.05);在給藥次數、住院天數方麵,聯閤組明顯少于對照組,差異有統計學意義(P＜0.01).結論 納洛酮聯閤長託寧治療中、重度有機燐農藥中毒,相對于單用長託寧或不使用長託寧的常規治療,能顯著提高治愈率,降低病死率,無疑為一種有效的治療方法.
목적 탐토납락동연합장탁저재중、중도유궤린농약중독적치료중적작용급림상응용.방법 장60례환자수궤분위연합조、장탁저조화대조조,매조20례.연합조재대조조기출상가용납락동,동시장아탁품개위장탁저;대조조채용전통방법,이아탁품연합록린정치료위주;장탁저조이장탁저대체아탁품,동시운용록해린정등약물.납락동수제정맥주사1.2 mg,수후정맥적주1.6 mg,련용5d.장탁저수제4 mg,기육주사,근거병정가량지아탁품화,병유지아탁품화.결과 연합조총유효솔(90.00％)고우장탁저조(75.00％)급대조조(50.00％),차이유통계학의의(P＜0.05);재급약차수、주원천수방면,연합조명현소우대조조,차이유통계학의의(P＜0.01).결론 납락동연합장탁저치료중、중도유궤린농약중독,상대우단용장탁저혹불사용장탁저적상규치료,능현저제고치유솔,강저병사솔,무의위일충유효적치료방법.
Objective To observe the therapeutic effect of penehyclidine hydrochloride combined with naloxone on moderate to severe organophosphorus pesticide poisoning.Methods Sixty cases of organophosphorus pesticide poisoning (taking orally)were randomly divided into penehyclidine hydrochloride-naloxone group,penehyclidine hydrochloride group and control group,20 cases in each group.Patients in penehyclidine hydrochloride-naloxone group were treated with penehyclidine hydrochloride and naloxone,patients in penehyclidine hydrochloride group were only given penehyclidine hydrochloride without naloxone,while patients in control group with pralidoxime chloride and atropine.Results The total effective rate in hydrochloride-naloxone group (90.00％) was higher than that in penehydidine hydrochloride group ( 75.00％ ) and control group ( 50.00％ ),there were significant differences ( P ＜ 0.05 ).The differences in times and totol dosage of drug administration,the adverse effects of the atropinization and the recovery time between the control group and pene hyclidine hydrochloride-naloxone group were significant ( P ＜ 0.01 ).The above-mentioned datas were significantly shorter in penehyclidine hydrochloride-naloxone group.Conclusions Penehyclidine hydrochloride combined with naloxone is more effective than traditional therapy of atropine for morderate to severe organophosphorus pesticides poisoning,which can increase the cure rate and lower the motality.
