CAJ | 학술논문

目的探讨高压氧(hyperbaric oxygen,HBO)预处理对提高皮肤缺血耐受的作用.方法 18只雄性SD大鼠分为HBO预处理组和对照组.HBO预处理组大鼠在手术前2 d行HBO治疗,对照组大鼠不做任何处理.麻醉后在大鼠腹部形成以右侧腹壁下浅动脉为带的扩大腹部皮瓣,大小约6 cm×9 cm.先用显微血管夹阻断皮瓣血供3 h,然后恢复皮瓣血供.术后第5天观察皮瓣成活情况.用硫酸纸按设计皮瓣和成活皮瓣形状剪成相应的纸模并用扫描仪将纸模转换为相应的皮瓣图像.用Acrobat软件计算分析皮瓣面积.数据用SPSS软件进行统计学分析.结果对照组和预处理组的平均皮瓣设计面积分别为(51.59±6.62)cm2和(52.71±2.05)cm2.平均成活面积分别为(7.38±2.49)cm2和(15.82±5.95)cm2.两组在皮瓣成活面积上差异有统计学意义(t=4.14,P<0.01).结论 HBO预处理能提高皮肤缺血耐受,提高皮瓣成活率.
목적 탐토고압양(hyperbaric oxygen,HBO)예처리대제고피부결혈내수적작용.방법 18지웅성SD대서분위HBO예처리조화대조조.HBO예처리조대서재수술전2 d행HBO치료,대조조대서불주임하처리.마취후재대서복부형성이우측복벽하천동맥위대적확대복부피판,대소약6 cm×9 cm.선용현미혈관협조단피판혈공3 h,연후회복피판혈공.술후제5천관찰피판성활정황.용류산지안설계피판화성활피판형상전성상응적지모병용소묘의장지모전환위상응적피판도상.용Acrobat연건계산분석피판면적.수거용SPSS연건진행통계학분석.결과 대조조화예처리조적평균피판설계면적분별위(51.59±6.62)cm2화(52.71±2.05)cm2.평균성활면적분별위(7.38±2.49)cm2화(15.82±5.95)cm2.량조재피판성활면적상차이유통계학의의(t=4.14,P<0.01).결론 HBO예처리능제고피부결혈내수,제고피판성활솔.
Objective To study the effect of preconditioning hyperbaric oxygenation on skin flap is-ehaemia tolerance. Methods 18 male SD rats were divided into the control and HBO preconditioning groups. In control group, an extended epigastrie adipocutaneous flap was raised, based on the right su-perficial epigastric artery and vein. 3-hours flap ischemia was induced by clamping the pedicle vessels with microvascular clamp. At the end of ischemia induction, the clamp was removed and the flap was sutured back. Rats in HBO preconditioning group were treated with HBO two days before operation. Flap surger-y began 1 hour after the last HBO treatment. The operation was the same as the control group. On the fifth postoperative day, the condition of the flap was recorded with transparent paper. Mean flap necrosis area was calculated with Acrobat software. Data were analyzed with SPSS software. Results The aver-age designed flap area was (51.59±6.62)cm2 and (52.71±2.05)cm2 in the control group and the HBO preconditioning group. The average flap survival area was (7.38±2.49)cm2 and (15.82±5.95)cm2. The difference was significant between the control and HBO preconditioning groups (t= 4. 14, P<0.01) in average flap survival area. Conclusion HBO preconditioning can rise flap ischaemia tolerance and enhance flap survival.