CAJ | 학술논문

趋化因子是一类调节免疫细胞定向迁移的细胞因子,其与表达于细胞表面的趋化因子受体结合而发挥生物学功能.树突状细胞(DC)是重要的专职抗原递呈细胞,其主要的应用是制备成各种肿瘤疫苗,树突状细胞功能的行使与趋化因子及其受体介导的细胞迁移密切相关,趋化因子在树突状细胞游走与迁徙过程中始终发挥着调节、促进或抑制的作用,从而促使树突状细胞递呈抗原、激活初始T细胞,引起机体免疫反应,杀伤、消灭肿瘤细胞和炎性分子.
추화인자시일류조절면역세포정향천이적세포인자,기여표체우세포표면적추화인자수체결합이발휘생물학공능.수돌상세포(DC)시중요적전직항원체정세포,기주요적응용시제비성각충종류역묘,수돌상세포공능적행사여추화인자급기수체개도적세포천이밀절상관,추화인자재수돌상세포유주여천사과정중시종발휘착조절、촉진혹억제적작용,종이촉사수돌상세포체정항원、격활초시T세포,인기궤체면역반응,살상、소멸종류세포화염성분자.
Chemokine can regulate the immuue cells migration, play the function by combining chemokine receptor. Dendritic cells(DC) are the most important professional antigen presenting cells, and their main application is prepared into a variety of cancer vaccine. Dendritic cells need to migrate while completing the functions, are related with chemokine and chemokine receptor. Chemokines always playe a regulating, promoting or inhibiting role in the processing of completing the functions and migration. So DC can present antigens, activate the initial T cells, cause immune response and kill the tumor cells and inflammatory molecules.