CAJ | 학술논문

肿瘤热疗可以通过抑制细胞DNA修复、改变细胞信号传导、调节细胞周期关卡及抑制肿瘤细胞转移等机制增加放射敏感性,许多临床试验也证实热放疗联合可以提高头颈部、胸腹部及盆腔恶性肿瘤的疗效.
종류열료가이통과억제세포DNA수복、개변세포신호전도、조절세포주기관잡급억제종류세포전이등궤제증가방사민감성,허다림상시험야증실열방료연합가이제고두경부、흉복부급분강악성종류적료효.
Thermotherapy is one of the combined therapies of malignant tumor. It can enhance the sen-sitivity to radiotherapy by inhibiting cell DNA repair,changing cell signaling, modulating cell cycle checkpoint and inhibiting tumor cell metastasis. Many clinical trials have also confirmed that the combination of thermother-apy and radiotherapy can enhance the curative effect of head and neck,ventrum and pelvic malignant tumor. In this article,the synergistic effects and mechanism of tumor thermoradiotherapy are reviewed.