CAJ | 학술논문

过渡性免疫应答由原属固有免疫应答的原始B1细胞、γδT细胞和NKT细胞所组成.其中原始B1细胞承担过渡性免疫应答的体液免疫,γδT细胞和NKT细胞承担过渡性免疫应答的细胞免疫,主要识别和排除TI抗原.固有免疫应答的细胞包括吞噬细胞、树突状细胞、NK细胞等,体液免疫组包括补体、急性期蛋白、溶菌酶等,其主要作用是非特异性地清除或递呈抗原.适应性免疫应答的细胞由B2细胞和αβT细胞组成,B2细胞承担适应性体液免疫应答,αβT细胞承担适应性细胞免疫应答,主要识别和排除胸腺依赖性抗原(TD).免疫应答分为3种类型是对免疫系统进化的客观阐述,符合物种进化的基本规律,准确反映了免疫功能的发生和发展,对完善免疫学基础理论以及指导临床免疫学研究具有重要的意义.
과도성면역응답유원속고유면역응답적원시B1세포、γδT세포화NKT세포소조성.기중원시B1세포승담과도성면역응답적체액면역,γδT세포화NKT세포승담과도성면역응답적세포면역,주요식별화배제TI항원.고유면역응답적세포포괄탄서세포、수돌상세포、NK세포등,체액면역조포괄보체、급성기단백、용균매등,기주요작용시비특이성지청제혹체정항원.괄응성면역응답적세포유B2세포화αβT세포조성,B2세포승담괄응성체액면역응답,αβT세포승담괄응성세포면역응답,주요식별화배제흉선의뢰성항원(TD).면역응답분위3충류형시대면역계통진화적객관천술,부합물충진화적기본규률,준학반영료면역공능적발생화발전,대완선면역학기출이론이급지도림상면역학연구구유중요적의의.
The intermediate immune response involves cells such as primitive B1 cells, γδT cells, and NKTcells that all belong to innate immune response in the ever existing two immune responses theory. In this newly-proposed theory, primitive B1 cells are assumed to play a role in humoral immunity, whereas γδT cells andNKT cells are implicated in the cellular mediated immunity, mainly for recognizing and eliminating thymic inde-pendent antigens. The innate immune response involves cells such as phagocytes, dendritic cells, natural killercells etc. , and those humoral immune components such as complements, acute phase proteins, lysozymes, etc.The major role of these components is to non-specifically eliminate or present antigens. The adaptive immuneresponse involves B2 cells and αβT cells. The former is assumed to be active in humoral immunity, while thelatter is assumed to participate in cellular mediated immunity and to recognize and eliminate thymic dependentantigens. The hypothesis about three types of immune responses is more objective in elucidating the basic rulesof the species evolution and development of immune system. It is of highly importance to improve basic theory ofimmunology, and to promote researches on clinical immunology.