CAJ | 학술논문

目的探讨碳酸锂合并奥氮平与碳酸锂单独治疗双相情感障碍期间患者血脂水平和体重变化.方法测定46例双相情感障碍患者采用碳酸锂合并奥氮平治疗6个月(一期)、之后再单独使用碳酸锂治疗6个月(二期)结束时的体重、血脂,并与治疗前进行比较.结果一期治疗结束时患者总胆固醇、三酰甘油、载脂蛋白B水平增高(P＜0.05);二期治疗结束时总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B水平进一步增高(P＜0.05),其中总胆固醇、三酰甘油和LDL-C超过正常水平,载脂蛋白虽增高,但未超过正常水平.一期治疗结束时患者体重为(68.70±8.35)kg，显著高于治疗前的(64.85±7.52)kg(P＜0.05)，二期治疗结束时患者体重为(71.72±7.96)kg,与一期治疗结束时比较差异有统计学意义(P＜0.05).男女性别分开统计后仍符合以上特点.结论碳酸锂合并奥氮平及碳酸锂单独治疗双相情感障碍期间均可导致患者的体重和血脂水平增高,以碳酸锂单独治疗期间血脂改变明显,增加了患冠心病的危险性.
목적 탐토탄산리합병오담평여탄산리단독치료쌍상정감장애기간환자혈지수평화체중변화.방법 측정46례쌍상정감장애환자채용탄산리합병오담평치료6개월(일기)、지후재단독사용탄산리치료6개월(이기)결속시적체중、혈지,병여치료전진행비교.결과 일기치료결속시환자총담고순、삼선감유、재지단백B수평증고(P＜0.05);이기치료결속시총담고순、삼선감유、저밀도지단백담고순(LDL-C)、재지단백B수평진일보증고(P＜0.05),기중총담고순、삼선감유화LDL-C초과정상수평,재지단백수증고,단미초과정상수평.일기치료결속시환자체중위(68.70±8.35)kg，현저고우치료전적(64.85±7.52)kg(P＜0.05)，이기치료결속시환자체중위(71.72±7.96)kg,여일기치료결속시비교차이유통계학의의(P＜0.05).남녀성별분개통계후잉부합이상특점.결론 탄산리합병오담평급탄산리단독치료쌍상정감장애기간균가도치환자적체중화혈지수평증고,이탄산리단독치료기간혈지개변명현,증가료환관심병적위험성.
Objective To study the changes of lipid levels and body weight during the treatment of bipolar disorder by lithium carbonate combined with olanzapine or lithium. Methods Lipid and body weight was measured in forty-six patients with bipolar disorder in the first six months (treated by lithium carbonate combined with olanzapine) and in the second six months (treated by lithium only). Then the results were compared with the data before the treatment. Results When the first six months was over,the levels of the total cholesterol, triglyceride and apolipoprotein B increased(P＜ 0.05 ) ,and when the second six months was over,the levels of the total cholesterol,triglyceride,low density lipoprotein cholesterol (LDL-C),and apolipoprotein B increased Significantly (P ＜ 0.05 ). The levels of the total cholesterol, triglyceride, LDL-C were more than the normal level,but apolipoprotein B didn't exceed the normal level. When the first six months was over, the body weight was higher than that before treatment [ (68.70 ± 8.35 ) kg vs. (64.85 ±7.52 ) kg, P ＜ 0.05 ]. When the second six months was over, the body weight [ (71.72 ± 7.96 ) kg ] was higher than that at the end of the first six months (P ＜ 0.05 ). Gender difference showed non-statistical significance.Conclusions The lipid levels and body weight will both increase whether treated with lithium carbonate combined with olanzapine or with lithium only. The lipid level changes apparently in treatment with lithium separately, and the risk of coronary heart disease will increase.