CAJ | 학술논문

早产儿视网膜病变( ROP)病因和发病机制尚不完全清楚,制约了其有效防治和相关研究的深入开展.尽管氧诱导视网膜病变动物模型为探索ROP复杂的病因和发病机制发挥了重要作用,但特异性较差,与人类ROP临床本质存在一定差异.因此,有必要对现有动物模型进行改良或建立新动物模型.通过更新观念、在多学科交叉中寻求突破,融合更多ROP危险因素,并结合新兴的转基因技术以及完善模型评价系统,建立科学的实验研究平台,为更好地开展ROP防治研究奠定基础.
조산인시망막병변( ROP)병인화발병궤제상불완전청초,제약료기유효방치화상관연구적심입개전.진관양유도시망막병변동물모형위탐색ROP복잡적병인화발병궤제발휘료중요작용,단특이성교차,여인류ROP림상본질존재일정차이.인차,유필요대현유동물모형진행개량혹건립신동물모형.통과경신관념、재다학과교차중심구돌파,융합경다ROP위험인소,병결합신흥적전기인기술이급완선모형평개계통,건립과학적실험연구평태,위경호지개전ROP방치연구전정기출.
The etiological factors and pathogenesis of retinopathy of prematurity (ROP) are still unclear,which restricted its effective prevention and treatment.The current animal model widely used in ROP investigation is oxygen-induced retinopathy model,which is lack of specificity,and does not mimic the real pathogenesis status of human ROP patients.Thus,we should refresh our concept,seek breakthroughs in multi-disciplines,integrate more risk factors of ROP,utilize the rising technique in transgenic animal,and improve the evaluation system for improving the current models or explore new animal models of ROP.It is important for prevention and treatment of ROP.