CAJ | 학술논문

背景:应用脑诱发电位技术比较强迫症和精神分裂症患者在听及视信息加工过程中感觉性脑诱发电位特征,是否可发现一些异常的生物学指标.目的:观察强迫症和精神分裂症患者感觉性脑诱发电位长潜伏期及听觉脑诱发电位的变化特征,并与健康人相比较.设计:随机抽样法,病例对照研究.地点和对象:病例组为宁波市康宁医院门诊和住院患者,对照组均为身心健康的志愿者.干预:利用意大利百胜公司GalileoSirius电生理仪对36例强迫症和36例精神分裂症患者用33例正常对照组进行了短声、闪光刺激,完成听觉脑诱发电位、视觉脑诱发电位.主要观察指标:观察主波出现率,各波的波幅和潜伏期.结果:发现与正常对照组相比,强迫症和精神分裂症患者无论在听觉诱发电位(auditory evoked potentials AEP),还是在视觉诱发电位(vi-sual evoked potentials VEP)中,其P3波出现率明显减少(x2=12.73,P＜0.01;x2=13.13,P＜0.01);其中VEP/P3出现率精神分裂症与强迫症相比更为减少(x2=34.62,P＜0.01).强迫症和精神分裂症患者的AEP/P2波呈双峰率现象均增高(x2=4.17,P＜0.05).强迫症、精神分裂症和正常对照组三组在相比,在AEP中潜伏期N1、P2波延长(F=6.95,P＜0.01;F=6.45,P＜0.01),波幅N1波下降(F=3.55,P＜0.05);VEP中P2潜伏期延长(F=6.16,P＜0.01),波幅P2,P3波均有改变(F=7.96,P＜0.01;F=12.06,P＜001).结论:强迫症和精神分裂症患者在听、视信息加工过程均有不同程度的异常,以精神分裂症为重,其异常指标与其发病机制和症状有关,值得关注.
배경:응용뇌유발전위기술비교강박증화정신분렬증환자재은급시신식가공과정중감각성뇌유발전위특정,시부가발현일사이상적생물학지표.목적:관찰강박증화정신분렬증환자감각성뇌유발전위장잠복기급은각뇌유발전위적변화특정,병여건강인상비교.설계:수궤추양법,병례대조연구.지점화대상:병례조위저파시강저의원문진화주원환자,대조조균위신심건강적지원자.간예:이용의대리백성공사GalileoSirius전생리의대36례강박증화36례정신분렬증환자용33례정상대조조진행료단성、섬광자격,완성은각뇌유발전위、시각뇌유발전위.주요관찰지표:관찰주파출현솔,각파적파폭화잠복기.결과:발현여정상대조조상비,강박증화정신분렬증환자무론재은각유발전위(auditory evoked potentials AEP),환시재시각유발전위(vi-sual evoked potentials VEP)중,기P3파출현솔명현감소(x2=12.73,P＜0.01;x2=13.13,P＜0.01);기중VEP/P3출현솔정신분렬증여강박증상비경위감소(x2=34.62,P＜0.01).강박증화정신분렬증환자적AEP/P2파정쌍봉솔현상균증고(x2=4.17,P＜0.05).강박증、정신분렬증화정상대조조삼조재상비,재AEP중잠복기N1、P2파연장(F=6.95,P＜0.01;F=6.45,P＜0.01),파폭N1파하강(F=3.55,P＜0.05);VEP중P2잠복기연장(F=6.16,P＜0.01),파폭P2,P3파균유개변(F=7.96,P＜0.01;F=12.06,P＜001).결론:강박증화정신분렬증환자재은、시신식가공과정균유불동정도적이상,이정신분렬증위중,기이상지표여기발병궤제화증상유관,치득관주.
BACKGROUND: Whether the application of cerebral evoked potential technique in the comparison of the sensory evoked potential during the auditory and visual information processing procedure between patients with obsessive-compulsive disorder and schizophrenia could discover any abnormal biological indices or not?OBJECTIVE: To observe the long latency of the sensory evoked potential and the variation of auditory evoked potential in patients with obsessive-compulsive disorder, which would be compared with that of normal individuals as well.DESIGN: A randomised case-controlled trial.SETTING and PARTICIPANTS: Patients of the outpatient and inpatient departments of Ningbo Kangning Hospital were selected in case group and healthy volunteers were selected in control group.INTERVENTIONS: Short tone and flash stimulation were conducted by GalileoSirius electrophysiology analyser made by Baisheng Company(Italy)in 36 patients with obsessive-compulsive disorder, 36 schizophrenes and 33normal individuals for the detection of auditory evoked potential and visual evoked potential.MAIN OUTCOME MEASURES: The detective rate of main wave, the amplitude and latency of each wave were observed.RESULTS: Compared with normal control group, in the auditory evoked potentials and visual evoked potentials of the patients with obsessive-compulsive disorder and schizophrenia, the detective rate of P3 wave significantly reduced(x2 = 12.73, P ＜ 0.01; x2 = 13.13, P ＜ 0.01 ). The detective rate of P3 in visual evoked potential of schizophrene was even less than that of patients with obsessive-compulsive disorder(x2 = 34.62, P＜ 0.01). The double peak P2 wave in auditory evoked potential increased in both patients (x2 =4. 17, P ＜ 0.05) . The comparisons among obsessive-compulsive disorder group, schizophrenia group and control group indicated that the N1latency and P2 wave prolonged in auditory evoked potential( F = 6.95, P ＜0.01; F = 6.45, P＜0.01 ) and N1 amplitude decreased( F = 55, P ＜0.05); P2 latency in visual evoked potential prolonged( F = 6. 16, P ＜0.01), and the amplitudes of P2 and P3 changed( F = 7.96, P ＜0.01;F= 12.06, P＜0.01).CONCLUSION: Patients of obsessive-compulsive disorder and schizophrenia have abnormities of different extent in the auditory and visual information processing procedure. Schizophrenes have more serious abnormities.