中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2010年
2期
147-150
,共4页
袁凤来%陈飞虎%陆伟国%李霞%吴繁荣%张腾跃%王玉
袁鳳來%陳飛虎%陸偉國%李霞%吳繁榮%張騰躍%王玉
원봉래%진비호%륙위국%리하%오번영%장등약%왕옥
酸敏感离子通道%功能%酸中毒%神经系统%非神经组织
痠敏感離子通道%功能%痠中毒%神經繫統%非神經組織
산민감리자통도%공능%산중독%신경계통%비신경조직
acid-sensing ion channels%functions%acidosis%nervous system%non-neuronal tissues
酸敏感离子通道(ASICs)是一类由细胞外酸化所激活的阳离子通道,属于钠通道超家族的新成员.近来发现,ASICs不但在神经系统具有重要的生物学功能,对神经系统以外的组织(如:味蕾、心血管、骨等)的生理和病理过程中也具有重要的作用.该文对有关ASICs在神经以外其他组织中研究的最新进展作一综述,以增进对ASICs生物学功能和病理作用的了解.
痠敏感離子通道(ASICs)是一類由細胞外痠化所激活的暘離子通道,屬于鈉通道超傢族的新成員.近來髮現,ASICs不但在神經繫統具有重要的生物學功能,對神經繫統以外的組織(如:味蕾、心血管、骨等)的生理和病理過程中也具有重要的作用.該文對有關ASICs在神經以外其他組織中研究的最新進展作一綜述,以增進對ASICs生物學功能和病理作用的瞭解.
산민감리자통도(ASICs)시일류유세포외산화소격활적양리자통도,속우납통도초가족적신성원.근래발현,ASICs불단재신경계통구유중요적생물학공능,대신경계통이외적조직(여:미뢰、심혈관、골등)적생리화병리과정중야구유중요적작용.해문대유관ASICs재신경이외기타조직중연구적최신진전작일종술,이증진대ASICs생물학공능화병리작용적료해.
Acid-sensing ion channels(ASICs) are a novel class of ligand-gated cation channels activated by extracellular acidification and belong to the epithelial sodium channels(DEG/ENaC) superfamily.Their biological functions have recently been found not only in the central nervous system but also relevant to the physiology and pathology of non-neuronal tissues such as taste buds, cardiovascular system and bones.This review concerns the latest research on the expression and functions of ASICs in non-neuronal tissues so as to promote the understanding of their physiological and pathological functions.
