中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2010年
1期
57-63
,共7页
艾效曼%陶凤蓉%宣天芝%陈东科%许宏涛%胡云建
艾效曼%陶鳳蓉%宣天芝%陳東科%許宏濤%鬍雲建
애효만%도봉용%선천지%진동과%허굉도%호운건
细菌耐药性监测%耐药性
細菌耐藥性鑑測%耐藥性
세균내약성감측%내약성
antibiotic resistance monitor%resistance
目的 了解2005年至2008年本院临床分离菌9005株对常用抗菌药物的耐药性.方法 用纸片Kirby-Bauer法,对本院4年分离的9005株临床分离株进行药物敏感性试验,Whonet 5.4统计软件对数据进行分析.结果 革兰阴性杆菌数量多于革兰阳性球菌.4年间,肺炎链球菌19株为青霉素不敏感株,β溶血链球菌未见青霉素耐药菌株,流感嗜血杆菌β内酰胺酶产酶率从2005年的13%下降至2008年的4.5%;未发现对万古霉素、利奈唑胺不敏感的葡萄球菌;屎肠球菌的耐药性高于粪肠球菌,万古霉素耐药的肠球菌(VRE)分离率有上升趋势;于2005至2008年,大肠埃希菌的产超广谱β内酰胺酶(ESBLs)分离率分别占43.0%,21.3%,52.0%及52.6%,肺炎克雷伯菌的ESBLs分离率分别占15.0%,25.9%,18.3%及25.0%;铜绿假单胞菌和不动杆菌属已出现多重耐药株.结论 定期进行耐药监测有助于了解细菌耐药性变迁.
目的 瞭解2005年至2008年本院臨床分離菌9005株對常用抗菌藥物的耐藥性.方法 用紙片Kirby-Bauer法,對本院4年分離的9005株臨床分離株進行藥物敏感性試驗,Whonet 5.4統計軟件對數據進行分析.結果 革蘭陰性桿菌數量多于革蘭暘性毬菌.4年間,肺炎鏈毬菌19株為青黴素不敏感株,β溶血鏈毬菌未見青黴素耐藥菌株,流感嗜血桿菌β內酰胺酶產酶率從2005年的13%下降至2008年的4.5%;未髮現對萬古黴素、利奈唑胺不敏感的葡萄毬菌;屎腸毬菌的耐藥性高于糞腸毬菌,萬古黴素耐藥的腸毬菌(VRE)分離率有上升趨勢;于2005至2008年,大腸埃希菌的產超廣譜β內酰胺酶(ESBLs)分離率分彆佔43.0%,21.3%,52.0%及52.6%,肺炎剋雷伯菌的ESBLs分離率分彆佔15.0%,25.9%,18.3%及25.0%;銅綠假單胞菌和不動桿菌屬已齣現多重耐藥株.結論 定期進行耐藥鑑測有助于瞭解細菌耐藥性變遷.
목적 료해2005년지2008년본원림상분리균9005주대상용항균약물적내약성.방법 용지편Kirby-Bauer법,대본원4년분리적9005주림상분리주진행약물민감성시험,Whonet 5.4통계연건대수거진행분석.결과 혁란음성간균수량다우혁란양성구균.4년간,폐염련구균19주위청매소불민감주,β용혈련구균미견청매소내약균주,류감기혈간균β내선알매산매솔종2005년적13%하강지2008년적4.5%;미발현대만고매소、리내서알불민감적포도구균;시장구균적내약성고우분장구균,만고매소내약적장구균(VRE)분리솔유상승추세;우2005지2008년,대장애희균적산초엄보β내선알매(ESBLs)분리솔분별점43.0%,21.3%,52.0%급52.6%,폐염극뢰백균적ESBLs분리솔분별점15.0%,25.9%,18.3%급25.0%;동록가단포균화불동간균속이출현다중내약주.결론 정기진행내약감측유조우료해세균내약성변천.
Objective To analyze the antibiotic resisitance of clinic iso-lated bacteria in Beijing Hospital from 2005 to 2008.Methods Making antibiotic sensitivity test of total 9005 strains isolated from patients in Bei-jing Hospital from 2005 to 2008 with K-B method;analyzing the data with Whonet 5.4 system.Results The total strains of gram negative ba-cilli were more than gram positive coccus.There are 19 Penicillin non-susceptible S.pneumoniae(PRSP).As to hemolytic streptococcus,none of them was resistant to penicillin.The β-lactamase producing rate of Haemophilus influenzae was decreased from 13% in 2005 to 4.5% in 2008.During 2008.the methicillin-resistant Staphylococcus aureus (MRSA)was 76.8%and that of methicillin-resistant coagulase-nage-tire Staphylococcus(MRSCoNS)was 69.0%.Vancomycin and linezolid resistance strains did not appear.The resistance rate of Enterococcus fae-cium was higher than that of Enterococcus faecalis.The resistant rates of Enterococcus.to vancomycin and teicoplanin had increasing tendency.The detection rate of extended-spectrum beta-lactamases(ESBLs)to E. coli Was 43.0%.21.3%,52.0%and 52.6%in 4 years.The detection rates of ESBLs to Klebiella pneumonia Was 15.0% 25.9%.18.3% and 25.0%.Multi-antibiotic resistant strains of Pseudomonas aerugirlosa and Acineto-bacter appeared.Conclusion In order to study the resistance and its tendency of bacteria isolated from patients in Beijing Hospital and offer the theory to clinicalians for experienced treat.
