CAJ | 학술논문

[目的]观察不同浓度的大黄水煎剂对乌鳢离体小肠运动性能的影响,并探讨其药理作用机制.[方法]采用离体器官法,利用RM6240B生物信号采集与处理系统,记录不同浓度的大黄水煎剂对离体肠道作用前后的张力值.[结果]药液浓度为0.062和0.125 g/ml的大黄水煎剂对乌鳢离体肠道收缩表现出明显的增强作用;药液浓度为0.250和0.500 g/ml的大黄水煎剂对乌鳢离体肠道收缩表现出抑制作用,在用药浓度0.500 g/ml前后差异极显著;随着大黄浓度的增大,其对乌鳢肠道运动的作用加强,而对收缩频率的影响不明显.[结论]大黄水煎剂对乌鳢离体肠道平滑肌的收缩活动有明显的效应.
[목적]관찰불동농도적대황수전제대오례리체소장운동성능적영향,병탐토기약리작용궤제.[방법]채용리체기관법,이용RM6240B생물신호채집여처리계통,기록불동농도적대황수전제대리체장도작용전후적장력치.[결과]약액농도위0.062화0.125 g/ml적대황수전제대오례리체장도수축표현출명현적증강작용;약액농도위0.250화0.500 g/ml적대황수전제대오례리체장도수축표현출억제작용,재용약농도0.500 g/ml전후차이겁현저;수착대황농도적증대,기대오례장도운동적작용가강,이대수축빈솔적영향불명현.[결론]대황수전제대오례리체장도평활기적수축활동유명현적효응.
[Objective]The research aimed to investigate the effects of different concentrations of water decoction of rhubarb on the isolated intestinal movement performance of Ophicephalus argus and discuss its pharmacological mechanism. [Method]Using RM6240C biological information collecting system, the tension values of isolated intestine before and after administration of water decoction of rhubarb at different concentrations were recorded by using isolated organ method. [Result]Water decoction of rhubarb at 0.062 and 0.125 g/ml showed obvious enhancement on the isolated intestinal contraction of Ophicephalus argus. Water decoction of rhubarb at 0.250 and 0.500 g/ml showed inhibition on the isolated intestinal contraction of Ophicephalus argus. The difference was extremely significant between the concentrations of lower than 0.500 g/ml and more than 0.500 g/ml. With the increasing of rhubarb concentration, the intestinal movement of Ophicephalus argus enhanced and the contraction frequency did not change obviously. [Conclusion]Water decoction of rhubarb had remarkable effects on contractive activity of isolated intestines smooth muscle of Ophicephalus argus.