CAJ | 학술논문

小干扰RNA(siRNA)是由双链RNA(dsRNA)经 Dicer 酶加工成的小分子片段.21～25nt的siRNA作为 RNA 干扰(RNAi)过程中的关键效应分子,在哺乳动物细胞中能够高特异性、高效性地抑制基因的表达.目前,RNAi 被广泛地应用于各种肿瘤的研究,在胃肠道肿瘤方面,针对肿瘤的发生发展、转移以及治疗等方面都有许多积极的研究探索.
소간우RNA(siRNA)시유쌍련RNA(dsRNA)경 Dicer 매가공성적소분자편단.21～25nt적siRNA작위 RNA 간우(RNAi)과정중적관건효응분자,재포유동물세포중능구고특이성、고효성지억제기인적표체.목전,RNAi 피엄범지응용우각충종류적연구,재위장도종류방면,침대종류적발생발전、전이이급치료등방면도유허다적겁적연구탐색.
SiRNA comes from double-stranded RNA,which is processed into a small molecular fragment by Dicer.21-25nt siRNA,as the key effector molecules to the RNAi process,can inhibit gene expression with high specificity and high efficiency in mammalian cells.Currently,RNAi has been widely applied in a variety of cancer.RNAi has many active research explorations of the tumor development,metastasis and treatment in gastrointestinal cancer.