国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
19期
1450-1453
,共4页
特发性嗜酸粒细胞增多综合征%格列卫
特髮性嗜痠粒細胞增多綜閤徵%格列衛
특발성기산립세포증다종합정%격렬위
Idiopathic hypereosinophilic syndrome%Gleevec
目的 提高临床医师对特发性嗜酸粒细胞增多综合征的认识.方法 分析一例特发性嗜酸粒细胞增多综合征患者的临床资料及诊治经过,并复习相关文献.结果 患者,男,27岁,因“咳嗽伴畏寒发热1周,痰中带血1d”入院.多次复查血常规提示血嗜酸粒细胞增高,肺部CT提示双侧胸腔积液,心包积液,诊断为特发性嗜酸粒细胞增多综合征,给予甲基泼尼松龙治疗无效,后行血清FIP1L1/PDGFRα融合基因检测,结果提示阳性,改格列卫治疗,复查血常规提示血嗜酸粒细胞恢复正常.结论特发性嗜酸粒细胞增多综合征比较少见,临床表现不典型,故临床医师应提高对本病的认识.
目的 提高臨床醫師對特髮性嗜痠粒細胞增多綜閤徵的認識.方法 分析一例特髮性嗜痠粒細胞增多綜閤徵患者的臨床資料及診治經過,併複習相關文獻.結果 患者,男,27歲,因“咳嗽伴畏寒髮熱1週,痰中帶血1d”入院.多次複查血常規提示血嗜痠粒細胞增高,肺部CT提示雙側胸腔積液,心包積液,診斷為特髮性嗜痠粒細胞增多綜閤徵,給予甲基潑尼鬆龍治療無效,後行血清FIP1L1/PDGFRα融閤基因檢測,結果提示暘性,改格列衛治療,複查血常規提示血嗜痠粒細胞恢複正常.結論特髮性嗜痠粒細胞增多綜閤徵比較少見,臨床錶現不典型,故臨床醫師應提高對本病的認識.
목적 제고림상의사대특발성기산립세포증다종합정적인식.방법 분석일례특발성기산립세포증다종합정환자적림상자료급진치경과,병복습상관문헌.결과 환자,남,27세,인“해수반외한발열1주,담중대혈1d”입원.다차복사혈상규제시혈기산립세포증고,폐부CT제시쌍측흉강적액,심포적액,진단위특발성기산립세포증다종합정,급여갑기발니송룡치료무효,후행혈청FIP1L1/PDGFRα융합기인검측,결과제시양성,개격렬위치료,복사혈상규제시혈기산립세포회복정상.결론특발성기산립세포증다종합정비교소견,림상표현불전형,고림상의사응제고대본병적인식.
Objective To improve the understanding of the clinical manifestations of idiopathic hypereosinophilic syndrome (IHES).Methods A case diagnosed wih IHES was reported and the related literature was reviewed.Results A 27-year old man came to our hospital for the complaint of fever,cough for one week and bloody phlegm for one day.His blood routine test revealed hypereosinophilic.The chest CT scan indicated pleural effusion in both lungs and pericardial effusion.He was diagnosed as IHES.By given methylprednisolone,the eosinophil counts didn't decline obviously,and the symptom was not relieved.Then the serum FIP1L1/PDGFRα fusion gene was detected and it showed positive result.The methylpredmsolone treatment was changed to Gleevec.Then the eosinophil counts of the patient returned to normal.Conclusions IHES is uncommon.Its clinical manifestation is not typical.We should improve the recognition of IHES.
