CAJ | 학술논문

目的观察激活蛋白-1(AP-1)、基质金属蛋白酶类(MMPs)在急性心肌梗死(AMI)患者心脏组织中的表达及意义.方法采用免疫组化技术分别榆测AP-1亚单位c-Jun、MMP-2及MMP-9在人正常及AMI心脏组织中的表达.结果 (1)正常心脏组织可少量表达c-Jun、MMP-2及MMP-9;在AMI心脏组织中c-Jun、MMP-2及MMP-9表达较正常心脏组织明显增加(P值均<0.05).(2)在AMI心脏组织中,MMP-9表达水平与c-Jun表达水平明显呈正相关(r=0.773,P<0.01).结论在AMI心脏组织中AP-1及MMPs表达均明显升高,提示AP-1转录激活及MMPs表达增加可能在AMI后心室重构中发挥重要的作用.
목적 관찰격활단백-1(AP-1)、기질금속단백매류(MMPs)재급성심기경사(AMI)환자심장조직중적표체급의의.방법 채용면역조화기술분별유측AP-1아단위c-Jun、MMP-2급MMP-9재인정상급AMI심장조직중적표체.결과 (1)정상심장조직가소량표체c-Jun、MMP-2급MMP-9;재AMI심장조직중c-Jun、MMP-2급MMP-9표체교정상심장조직명현증가(P치균<0.05).(2)재AMI심장조직중,MMP-9표체수평여c-Jun표체수평명현정정상관(r=0.773,P<0.01).결론 재AMI심장조직중AP-1급MMPs표체균명현승고,제시AP-1전록격활급MMPs표체증가가능재AMI후심실중구중발휘중요적작용.
Objective To investigate the expression and significance of activator protein-1 (AP-1)and matrix metalloproteinases (MMPs) in acute myocardial infarction (AMI) subjects. Methods Immunohistochemical techniques were used to detect the subunit of AP-1 (c-Jun), MMP-2 and MMP-9 in human AMI and normal heart tissue and the expressions of c-Jun and MMPs were measured with computer image analysis system. Results (1) There were expressions of c-Jun, MMP-2 and MMP-9 in normal heart tissue, mainly in myocardial cells and cardiac fibroblasts, and their expressions in AMI myocardial tissues were all significantly higher than those in normal myocardial tissues (P <0.05). (2) The level of MMP-9expression was significantly and positively correlated with c-Jun in AMI heart tissue (r=0.773, P < 0.01).Conclusions The expressions of AP-1 and MMPs increase in human myocardial infarction. These findings suggest that AP-1 transcription activation pathway and MMPs may play an important role in ventricular remodeling of myocardial infarction.