CAJ | 학술논문

背景:随着镁离子对缺血性脑损伤治疗的研究进展,人们越来越重视镁对缺血性脑损伤的神经保护作用.镁对缺血性脑血管病的治疗已有报道,但对脑梗死患者诱发电位的研究国内外报道较少.目的:通过研究镁剂对脑梗死患者体感诱发电位的影响,证实镁剂的脑保护作用.设计:以诊断为依据的病例对照研究.地点和对象:选择2000-01/2001-12在聊城市第三人民医院神经内科确诊脑梗死患者60例,分为治疗组30例,男16例,女14例;年龄36～72岁,平均(62±4)岁.病变部位:基底核区18例,放射冠区8例,大脑半球4例.对照组30例,男15例,女15例;年龄37～75岁,平均(63±5)岁.病变部位:基底核区16例,放射冠区9例,大脑半球5例.方法:治疗组均在12 h内应用250 g/L硫酸镁20 mL静滴,1次/d,连用7 d,14 d后进行前后体感诱发电位的比较.对照组除不用硫酸镁外,其余治疗均同治疗组.主要观察指标:体感诱发电位反应形式,神经功能缺损评分.结果:治疗组体感诱发电位治疗前后变化显著且逐渐好转.治疗组治疗前神经功能缺损评分12.60±5.31,治疗后神经功能缺损评分7.41±4.35,差异有显著意义(t=4.141,P＜0.01);对照组治疗前神经功能缺损评分12.80±7.01,治疗后神经功能缺损评分12.80±5.37,差异有显著意义(t=2.99,P＜0.05).两组治疗前后神经功能缺损评分均明显降低,但治疗组较对照组减少更明显.结论:镁剂对脑梗死患者体感诱发电位的好转有显著影响,说明镁剂有明显的脑保护作用.
배경:수착미리자대결혈성뇌손상치료적연구진전,인문월래월중시미대결혈성뇌손상적신경보호작용.미대결혈성뇌혈관병적치료이유보도,단대뇌경사환자유발전위적연구국내외보도교소.목적:통과연구미제대뇌경사환자체감유발전위적영향,증실미제적뇌보호작용.설계:이진단위의거적병례대조연구.지점화대상:선택2000-01/2001-12재료성시제삼인민의원신경내과학진뇌경사환자60례,분위치료조30례,남16례,녀14례;년령36～72세,평균(62±4)세.병변부위:기저핵구18례,방사관구8례,대뇌반구4례.대조조30례,남15례,녀15례;년령37～75세,평균(63±5)세.병변부위:기저핵구16례,방사관구9례,대뇌반구5례.방법:치료조균재12 h내응용250 g/L류산미20 mL정적,1차/d,련용7 d,14 d후진행전후체감유발전위적비교.대조조제불용류산미외,기여치료균동치료조.주요관찰지표:체감유발전위반응형식,신경공능결손평분.결과:치료조체감유발전위치료전후변화현저차축점호전.치료조치료전신경공능결손평분12.60±5.31,치료후신경공능결손평분7.41±4.35,차이유현저의의(t=4.141,P＜0.01);대조조치료전신경공능결손평분12.80±7.01,치료후신경공능결손평분12.80±5.37,차이유현저의의(t=2.99,P＜0.05).량조치료전후신경공능결손평분균명현강저,단치료조교대조조감소경명현.결론:미제대뇌경사환자체감유발전위적호전유현저영향,설명미제유명현적뇌보호작용.
BACKGROUND: With the advance of studies on the therapeutic effect of magnesium ion on ischemic brain trauma, more attention has been paid to its neuroprotective role. Although quite a few reports on the treatment of ischemic cerebrovascular diseases with magnesium have been published, few literature on the influence of magnesium on somatosensory evoked potential (SEP) in patients with cerebral infarction can be found both at home and abroad.OBJECTIVE: To demonstrate the cerebroprotective role of magnesium by investigating its influence on SEP in patients with cerebral infarction.DESIGN: A case-control study base on clinical diagnosis.SETTING and SUBJECTS: Between January 2000 and December 2001,sixty patients with confirmed cerebral infarction in the Neurophysiological Department of the Third People' s Hospital in Liaocheng City, Liaoning Province, were included in this trial and randomly divided into two groups.In the treating group( n = 30), there were 16 males and 14 females, aged from 36 to 72 years old with the mean age of(62 ±4); lesions were found in basal gonglions of 18 cases, radiation coronal of 8 cases and hemisphere of 4 cases. The control group consisted of 15 males and 15 females, aged from 37 to 75 years old with the mean age of(63 ±5) years old; infarctions were found in basal gonglions of 16 cases, radiation coronal of 9 cases and hemisphere of 5 cases.METHODS: Patients in treatment group received intravenous injection of 20 mL magnesium sulfate of 250 g/L in 12 hours, once per day for consecutive 7 days. SEPs were compared before and after treatment with those of control group, in which the patients received the similar treatment but without magnesium sulfate.MAIN OUTCOME MEASUREMENTS: SEP response property and nerve functional impairment scores ( NFIS).RESULTS: SEP was obviously improved after magnesium administration in treatment group. Pretreatment NFIS was 12.60 ±5.31 and pest-treatment NFIS was 7.41 ±4. 35( t =4. 141, P ＜ 0. 01) . NFIS in control group was 12.80 ±7.01 and 12. 80 ±5.37 before and after treatment, respectively ( t = 2.99, P ＜ 0.05 ) . NFISs in both groups significantly decreased after treatment, and decrease of NFIS in the treatment group was more significant than that in the control group.CONCLUSION: Magnesium was beneficial for the significant improvement of SEP in patients with cerebral infarction, indicating apparent neuroprotective role.