中国病理生理杂志
中國病理生理雜誌
중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2009年
12期
2344-2348
,共5页
黄俊%汪建平%王磊%刘焕亮%魏宜胜%黄美近%傅新晖%陈静%陈典克
黃俊%汪建平%王磊%劉煥亮%魏宜勝%黃美近%傅新暉%陳靜%陳典剋
황준%왕건평%왕뢰%류환량%위의성%황미근%부신휘%진정%진전극
结直肠肿瘤%基因%survivin%多态性%单核苷酸
結直腸腫瘤%基因%survivin%多態性%單覈苷痠
결직장종류%기인%survivin%다태성%단핵감산
Colorectal neoplasms%Genes,survivin%Polymorphism,single nucleotide
目的:探讨生存素survivin基因启动子区-31C/G单核苷酸多态性与中国华南地区散发性结直肠癌(CRC)易感性的关系. 方法: 采用聚合酶链反应-限制性片段长度多态性法(PCR-RFLP)检测华南地区711例健康人和702例CRC的survivin基因-31C/G位点单核苷酸多态性.结果: 结直肠癌患者CC基因型的频率明显高于对照人群(36.5% vs 26.2 %,χ~2=17.89,P<0.01),与CC基因型相比,CG、GG基因型和等位基因G携带者的CRC发病风险分别显著下降至0.61倍(95%CI=0.46-0.80,P<0.01)、0.52倍(95%CI=0.38-0.71,P<0.01)和0.58倍(95%CI=0.45-0.74,P<0.01).结论: survivin基因-31C/G多态与CRC发病风险有关,-31G变异基因型是中国南方人群散发性结直肠癌独立保护因素.
目的:探討生存素survivin基因啟動子區-31C/G單覈苷痠多態性與中國華南地區散髮性結直腸癌(CRC)易感性的關繫. 方法: 採用聚閤酶鏈反應-限製性片段長度多態性法(PCR-RFLP)檢測華南地區711例健康人和702例CRC的survivin基因-31C/G位點單覈苷痠多態性.結果: 結直腸癌患者CC基因型的頻率明顯高于對照人群(36.5% vs 26.2 %,χ~2=17.89,P<0.01),與CC基因型相比,CG、GG基因型和等位基因G攜帶者的CRC髮病風險分彆顯著下降至0.61倍(95%CI=0.46-0.80,P<0.01)、0.52倍(95%CI=0.38-0.71,P<0.01)和0.58倍(95%CI=0.45-0.74,P<0.01).結論: survivin基因-31C/G多態與CRC髮病風險有關,-31G變異基因型是中國南方人群散髮性結直腸癌獨立保護因素.
목적:탐토생존소survivin기인계동자구-31C/G단핵감산다태성여중국화남지구산발성결직장암(CRC)역감성적관계. 방법: 채용취합매련반응-한제성편단장도다태성법(PCR-RFLP)검측화남지구711례건강인화702례CRC적survivin기인-31C/G위점단핵감산다태성.결과: 결직장암환자CC기인형적빈솔명현고우대조인군(36.5% vs 26.2 %,χ~2=17.89,P<0.01),여CC기인형상비,CG、GG기인형화등위기인G휴대자적CRC발병풍험분별현저하강지0.61배(95%CI=0.46-0.80,P<0.01)、0.52배(95%CI=0.38-0.71,P<0.01)화0.58배(95%CI=0.45-0.74,P<0.01).결론: survivin기인-31C/G다태여CRC발병풍험유관,-31G변이기인형시중국남방인군산발성결직장암독립보호인소.
AIM: To investigate the association between -31C/G polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer (CRC) in southern Chinese population. METHODS: survivin -31C/G genotypes were determined by PCR-RFLP in 711 healthy controls and 702 CRC cases. RESULTS: The number
of CRC patients carrying with CC genotype was much higher than that of controls (36.5 % vs 26.2%,χ~2 =17.89,P<0.01). Compared to CC genotypes, CG, GG genotypes and G allele carriers had a significantly decreased risk of CRC, with the decrease being 0.61-fold (95% confidence interval=0.46-0.80, P<0.01), 0.52-fold (95% confidence interval=0.38-0.71,P<0.01) and 0.58-fold (95% confidence interval=0.45-0.74, P<0.01), respectively. CONCLUSION: survivin gene -31C/G polymorphism is associated with sporadic CRC risk, the G variant genotype is the independent protective factors against sporadic CRC in southern Chinese population.
