中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
5期
615-617,621
,共4页
糖尿病,2型/并发症/代谢/血液%高甘油三酯血症/并发症/代谢/血液%网膜/代谢%烟酰胺磷酸核糖基转移酶/代谢/血液
糖尿病,2型/併髮癥/代謝/血液%高甘油三酯血癥/併髮癥/代謝/血液%網膜/代謝%煙酰胺燐痠覈糖基轉移酶/代謝/血液
당뇨병,2형/병발증/대사/혈액%고감유삼지혈증/병발증/대사/혈액%망막/대사%연선알린산핵당기전이매/대사/혈액
Diabetes mellitus,type 2/complications/metabolism/blood%Hypertriglyceridemia/complications/ metabolism/blood%Omentum/metaholism%Nicotinamide phosphoribosyltransferase/metabolism/blood
目的 探讨内脂素( visfatin)基因在2型糖尿病(T2DM)患者网膜脂肪组织中的表达情况及与血脂的关系.方法 选取2型糖尿病患者161例,分为高甘油三酯及正常甘油三酯两组.采用Northern blot印迹技术研究两组的网膜脂肪组织中visfatin mRNA的表达水平,并测定血清visfatin浓度、空腹血糖、血脂谱及其他生化指标.结果 (1)2型糖尿病伴高甘油三酯血症组血清visfatin增高[( 129.07±21.35) ng/mL vs(101.65±15.23) ng/mL,t =2.295,P＜0.05],网膜组织的visfatin mRNA表达量高于正常甘油三酯组(P＜0.05).(2)血清visfatin与甘油三酯(β=0.592,P＜0.05)及空腹血糖(β=0.763,P＜0.01)呈正相关,网膜脂肪组织visfatin与空腹血糖、甘油三酯等均无相关.结论 T2DM患者血清visfatin可能与甘油三酯代谢相关.
目的 探討內脂素( visfatin)基因在2型糖尿病(T2DM)患者網膜脂肪組織中的錶達情況及與血脂的關繫.方法 選取2型糖尿病患者161例,分為高甘油三酯及正常甘油三酯兩組.採用Northern blot印跡技術研究兩組的網膜脂肪組織中visfatin mRNA的錶達水平,併測定血清visfatin濃度、空腹血糖、血脂譜及其他生化指標.結果 (1)2型糖尿病伴高甘油三酯血癥組血清visfatin增高[( 129.07±21.35) ng/mL vs(101.65±15.23) ng/mL,t =2.295,P＜0.05],網膜組織的visfatin mRNA錶達量高于正常甘油三酯組(P＜0.05).(2)血清visfatin與甘油三酯(β=0.592,P＜0.05)及空腹血糖(β=0.763,P＜0.01)呈正相關,網膜脂肪組織visfatin與空腹血糖、甘油三酯等均無相關.結論 T2DM患者血清visfatin可能與甘油三酯代謝相關.
목적 탐토내지소( visfatin)기인재2형당뇨병(T2DM)환자망막지방조직중적표체정황급여혈지적관계.방법 선취2형당뇨병환자161례,분위고감유삼지급정상감유삼지량조.채용Northern blot인적기술연구량조적망막지방조직중visfatin mRNA적표체수평,병측정혈청visfatin농도、공복혈당、혈지보급기타생화지표.결과 (1)2형당뇨병반고감유삼지혈증조혈청visfatin증고[( 129.07±21.35) ng/mL vs(101.65±15.23) ng/mL,t =2.295,P＜0.05],망막조직적visfatin mRNA표체량고우정상감유삼지조(P＜0.05).(2)혈청visfatin여감유삼지(β=0.592,P＜0.05)급공복혈당(β=0.763,P＜0.01)정정상관,망막지방조직visfatin여공복혈당、감유삼지등균무상관.결론 T2DM환자혈청visfatin가능여감유삼지대사상관.
Objective To investigate the expression of visfatin mRNA in abdominal omental adipose tissue and its relationship with blood lipid in type 2 diabetes mellitus.Methods 161 type 2 diabetic patients were divided into two groups according to triglyceride ( TG ),high triglyceride group ( TG ≥ 1.7mmol/L) and normal triglyceride group(TG ＜ 1.7 mmol/L).The expression of visfatin mRNA in abdominal omental adipose tissue was measured with Northern Blot.Visfatin plasma concentration,fasting plasma glucose (FPG),blood lipid profiles and other biochemical indicators were also measured.Results Comparing with normal triglyceride group,the diabetic patients in high triglyceride group had significantly increased levels of visfatin plasma concentration [ ( 129.07 ± 21.35)ng/mL vs ( 101.65 ± 15.23 ) ng/mL,t =2.295,P ＜0.05]and mRNA expression in omental adipose tissue( P ＜0.05).Visfatin plasma concentration was positively correlated with TG( β =0.592,P ＜0.05 ) and FPG( β =0.763,P ＜0.01 ).Visfatin mRNA expression in omental adipose tissue had no correlation with FPG,TG and other biochemical indicators.Conclusions The plasma visfatin level in T2DM patients may be associated with triglyceride metabolism.
