CAJ | 학술논문

目的研究蒽环类药物累积剂量与血清心肌肌钙蛋白T(cTnT)水平的关系.方法回顾性分析2004年1月至2009年1月应用蒽环类药物化疗的88例急性白血病患者cTnT水平及其蒽环类药物累积剂量,以某一累积剂量水平分组计算各组cTnT升高的发生率.结果蒽环类药物累积剂量<200 mg/m~2组51例,1例cTnT水平升高,蒽环类药物累积剂量≥200 mg/m~2组37例,8例cTnT水平升高,两组cTnT升高的发生率差异有统计学意义(P<0.05).结论葸环类药物达到一定剂量时,cTnT升高发生率明显升高.
목적 연구은배류약물루적제량여혈청심기기개단백T(cTnT)수평적관계.방법 회고성분석2004년1월지2009년1월응용은배류약물화료적88례급성백혈병환자cTnT수평급기은배류약물루적제량,이모일루적제량수평분조계산각조cTnT승고적발생솔.결과 은배류약물루적제량<200 mg/m~2조51례,1례cTnT수평승고,은배류약물루적제량≥200 mg/m~2조37례,8례cTnT수평승고,량조cTnT승고적발생솔차이유통계학의의(P<0.05).결론 사배류약물체도일정제량시,cTnT승고발생솔명현승고.
Objective To study the relationship of accumulated dose of anthracycline(ANTH) with the cTnT level in acute leukemia patients. Methods The cTnT levels and the accumulated dose of anthracycline (ANTH) of 88 acute leukemia patients who were treated with anthracycline in our hospital from 2004-2009 who were treated with anthracycline. All the patients were divided into two groups according to a certain cTnT level,and the each incidence of elevated cTnT was obtained. Results 8 of 37 patients who received ≥200 mg/m2 of ANTH versus 1 of 51 patients who received <200 mg/m2 of ANTH had a higher incidence of elevated cTnT (P <0.05). Conclusion Incidence of elevated cTnT increases when the ANTH reaches the certain dose.