CAJ | 학술논문

胰腺癌的治疗主要是手术切除,但适应者仅20％,且治疗效果也不佳.虽然非手术治疗的效果很差,但化疗的地位已被确立,而放疗的地位尚未被完全肯定.现代的放疗作为局部治疗的手段参与胰腺癌的治疗,已经开始显现有可能改善肿瘤局控,提高生存率,有望成为胰腺癌局部治疗的一部分,但到目前还缺乏高级别的循证医学证据支持.就放疗技术本身而言,也存在诸多未解决的问题,包括照射靶区运动,靶区的定义,合适的分割剂量,总剂量和照射时间,放疗和手术、化疗的应用次序.然而下述观点是业界的共识:现代的放疗技术值得进一步研究,以明确其在胰腺癌综合治疗中的作用和地位.
이선암적치료주요시수술절제,단괄응자부20％,차치료효과야불가.수연비수술치료적효과흔차,단화료적지위이피학립,이방료적지위상미피완전긍정.현대적방료작위국부치료적수단삼여이선암적치료,이경개시현현유가능개선종류국공,제고생존솔,유망성위이선암국부치료적일부분,단도목전환결핍고급별적순증의학증거지지.취방료기술본신이언,야존재제다미해결적문제,포괄조사파구운동,파구적정의,합괄적분할제량,총제량화조사시간,방료화수술、화료적응용차서.연이하술관점시업계적공식:현대적방료기술치득진일보연구,이명학기재이선암종합치료중적작용화지위.
Surgery is the treatment of choice for pancreatic carcinoma.However,only 20％ of patients are eligible for surgery,and local control of disease and survival are not good.Although non-surgical treatments result in poor outcome,chemotherapy has been shown to be an effective treatment.The role of irradiation has not been well-established.Modern irradiation technology has shown promising results but there is still lack of strong prospective research evidence to support its widespread use.Irradiation brings along problems which need to be resolved,including target motion,definition of irradiation target,optimal fractionation,total treatment time and the treatment sequence of surgery,chemotherapy and radiation therapy.