CAJ | 학술논문

目的探讨胰岛素样生长因子ⅡmRNA结合蛋白3(IMP3)在膀胱移行细胞癌(BTCC)患者中的表达及其临床意义.方法采用免疫组织化学方法检测48例BTCC患者(BTCC组)的标本及6例正常膀胱组织(对照组)中IMP3的表达情况,并分析其表达同患者年龄、性别、肿瘤的临床分期、病理分级的关系.结果 IMP3在BTCC组中的阳性表达率62.5%(30/48)明显高于对照组(表达均为阴性),差异有统计学意义(χ2=8.615,P=0.003);IMP3在浅表组(12/22,46.15%)、低级别组[G1级12.5%(1/8),G2级60.0%(12/20)]表达明显低于其在浸润性(T2及以上,18/22,81.8%,P＜0.05),高级别(17/20,85%,P＜0.05)膀胱移行细胞癌中的表达.结论 IMP3对于BTCC患者是一种非常有前景的肿瘤标志物,可用于BTCC的早期临床诊断及BTCC早期恶性程度的评估.
목적 탐토이도소양생장인자ⅡmRNA결합단백3(IMP3)재방광이행세포암(BTCC)환자중적표체급기림상의의.방법 채용면역조직화학방법검측48례BTCC환자(BTCC조)적표본급6례정상방광조직(대조조)중IMP3적표체정황,병분석기표체동환자년령、성별、종류적림상분기、병리분급적관계.결과 IMP3재BTCC조중적양성표체솔62.5%(30/48)명현고우대조조(표체균위음성),차이유통계학의의(χ2=8.615,P=0.003);IMP3재천표조(12/22,46.15%)、저급별조[G1급12.5%(1/8),G2급60.0%(12/20)]표체명현저우기재침윤성(T2급이상,18/22,81.8%,P＜0.05),고급별(17/20,85%,P＜0.05)방광이행세포암중적표체.결론 IMP3대우BTCC환자시일충비상유전경적종류표지물,가용우BTCC적조기림상진단급BTCC조기악성정도적평고.
Objective To investigate the expression of insulin-like growth factor Ⅱ mRNA-binding protein 3( IMP3 ) in transitional cell carcinoma of bladder( TCCB ) and its clinical significance. Methods The IMP3 expressions in 6 normal bladder tissues and 48 TCCB tissues were determined by immunohistochemistry staining, and the relationships between IMP3 expression and gender, age, pathological grading and staging were analyzed statistically. Results The positive expression rate of IMP3 was 62.5% ( 30/48 ) in bladder cancer,which were significantly higher than that in normal control ( 0/6 ) ( P ＜ 0. 05 ). The positive rate of IMP3 expression were significantly lower in superficial TCCB ( 46. 15%, 12/22 ) or early TCCB [ Grade Ⅰ 12. 5%(1/8) ,Grade Ⅱ 60. 0% (12/20) ] than that in invasive TCCB [T2 or above,81.8% (18/22) ] or advanced TCCB [ Grade Ⅲ ,85% ( 17/20 ) ] ( Ps ＜ 0. 05 ). Conclusion IMP3 is a promising biomarker for eraly detection and assessment of the malignancy degree in TCCB.