CAJ | 학술논문

糖尿病主要由于其急性和慢性并发症使患者的生活质量和存活率降低.胰腺移植能将患者的血糖恢复到正常范围,并控制其并发症的发展,进而改善患者的生活质量和存活率.虽然胰腺移植需要进行较大的手术以及术后需要终身使用免疫抑制剂,但目前仍是传统治疗1型糖尿病无效的最佳治疗方法.同时,本文还对目前有可能替代胰腺移植的治疗方法,如胰岛移植、胰岛素产生细胞替代治疗以及人工胰腺等进行评述.
당뇨병주요유우기급성화만성병발증사환자적생활질량화존활솔강저.이선이식능장환자적혈당회복도정상범위,병공제기병발증적발전,진이개선환자적생활질량화존활솔.수연이선이식수요진행교대적수술이급술후수요종신사용면역억제제,단목전잉시전통치료1형당뇨병무효적최가치료방법.동시,본문환대목전유가능체대이선이식적치료방법,여이도이식、이도소산생세포체대치료이급인공이선등진행평술.
Diabetes mellitus impacts patient survival and quality of life mainly due to its acute and chronic complications.Pancreas transplantation may restore normoglycemia and reduce the complication of insulin-dependent diabetes,thus improving the quality of life and prolonging patient's survival.Although pancreas transplantation requires major surgery and life-long immunosuppression therapy,it currently remains the gold stand for patients with type 1 diabetes mellitus,who do not respond to conventional therapy.Meanwhile,potential of the islet transplantation,insulin-producing cells replacement therapy,and artificial pancreas as the alternative to pancreas transplantation are under investigation.