CAJ | 학술논문

目的研究2000～2009年世界各地不同物种的新型H1N1流感病毒HA1基因演变特征.方法从NCBI数据库下载所需序列,采用生物信息软件对其氨基酸序列进行基因特性分析以及构建种系发生树.结果病毒株HA1基因抗原决定簇和多个受体结合位点发生变异,并且新型病毒与猪H1N1流感病毒在大多数变异位点的氨基酸相同.结论新型毒株HA1基因可能由早期来自北美洲的H1N1猪流感病毒进化而来,在进化过程中,一些重要位点的变异导致HA1基因发生抗原性变异,从而导致流感的大爆发.
목적 연구2000～2009년세계각지불동물충적신형H1N1류감병독HA1기인연변특정.방법 종NCBI수거고하재소수서렬,채용생물신식연건대기안기산서렬진행기인특성분석이급구건충계발생수.결과 병독주HA1기인항원결정족화다개수체결합위점발생변이,병차신형병독여저H1N1류감병독재대다수변이위점적안기산상동.결론 신형독주HA1기인가능유조기래자북미주적H1N1저류감병독진화이래,재진화과정중,일사중요위점적변이도치HA1기인발생항원성변이,종이도치류감적대폭발.
Objective To study the global evolutionary characteristics of hemagglutinin gene HA1 of influenza H1N1 infecting-different species during 2000-2009. Methods The target sequences were downloaded from NCBI and analyzed using bioinformatic software to construct the phylogenetic tree. Results The HA1 amino acid sequences of influenza H1N1 contained four mutated antigenic sites and receptor-binding sites, and the novel influenza virus shared most of the mutated amino acid sites with swine H1N1 influenza virus. Conclusion The HA1 gene of novel influenza virus might originate from the early swine H1N1 influenza virus from North America, and in the evolutionary process, a number of important sites of HA1 gene mutated to result in the outbreak of influenza.