CAJ | 학술논문

目的:探讨左室壁内缩短分数(mFS )评价高血压患者收缩功能及其与左室舒张功能的关系.方法:收集高血压组51例,正常对照组47例.分析临床特点,行超声心动图检查.收缩功能测定左室室壁厚度,左室内径,左室容量,测定射血分数(EF),缩短分数(FS)以及左室mFS.心脏舒张功能,取二尖瓣血流频谱,记录二尖瓣舒张期血流频谱,记录舒张早期(E)和舒张晚期(A)血流速度峰值.采用组织速度多普勒成像技术测定二尖瓣环室间隔侧和侧壁侧的舒张早期心肌运动速度(Em)和舒张晚期心肌运动速度(Am),取平均值.探讨左室收缩功能和舒张功能的相关性.结果:①收缩功能:高血压组与正常对照组比较:左室舒张末间隔厚度明显增加[(1.18±0.28):(0.95±0.13),P<0.001]、左室舒张末后壁厚度明显增加[(1.01± 0.17):(0.89±0.17),P<0.01]、左室mFS明显降低[( 18.0± 4.9) vs (22.3±5.9), P<0.01],而2组间左室EF和FS差异无统计学意义.②舒张功能:高血压组与对照组比较,二尖瓣血流频谱差异无统计学意义;组织多普勒成像显示,二尖瓣环Em明显降低[(8.22± 2.23):(9.91±2.52),P<0.05],二尖瓣环Em/Am明显降低[(0.72± 0.23):(0.98±0.26),P<0.01]、二尖瓣E/Em明显增加[(9.38±3.19):(7.45±2.10), P<0.01].③mFS与Em/Am显著正相关(r=0.55,P<0.001 )、与E/Em显著负相关(r=-0.38,P<0.05).左室EF和FS与上述指标无相关性.结论:左室mFS是评价高血压患者收缩功能的有力指标,与早期舒张功能受损有关.
목적:탐토좌실벽내축단분수(mFS )평개고혈압환자수축공능급기여좌실서장공능적관계.방법:수집고혈압조51례,정상대조조47례.분석림상특점,행초성심동도검사.수축공능측정좌실실벽후도,좌실내경,좌실용량,측정사혈분수(EF),축단분수(FS)이급좌실mFS.심장서장공능,취이첨판혈류빈보,기록이첨판서장기혈류빈보,기록서장조기(E)화서장만기(A)혈류속도봉치.채용조직속도다보륵성상기술측정이첨판배실간격측화측벽측적서장조기심기운동속도(Em)화서장만기심기운동속도(Am),취평균치.탐토좌실수축공능화서장공능적상관성.결과:①수축공능:고혈압조여정상대조조비교:좌실서장말간격후도명현증가[(1.18±0.28):(0.95±0.13),P<0.001]、좌실서장말후벽후도명현증가[(1.01± 0.17):(0.89±0.17),P<0.01]、좌실mFS명현강저[( 18.0± 4.9) vs (22.3±5.9), P<0.01],이2조간좌실EF화FS차이무통계학의의.②서장공능:고혈압조여대조조비교,이첨판혈류빈보차이무통계학의의;조직다보륵성상현시,이첨판배Em명현강저[(8.22± 2.23):(9.91±2.52),P<0.05],이첨판배Em/Am명현강저[(0.72± 0.23):(0.98±0.26),P<0.01]、이첨판E/Em명현증가[(9.38±3.19):(7.45±2.10), P<0.01].③mFS여Em/Am현저정상관(r=0.55,P<0.001 )、여E/Em현저부상관(r=-0.38,P<0.05).좌실EF화FS여상술지표무상관성.결론:좌실mFS시평개고혈압환자수축공능적유력지표,여조기서장공능수손유관.
Objective:To investigate the association between diastolic function and systolic function assessed by mid-wall fractional shortening(mFS) in patients with hypertension. Method:There were 51 cases of hypertension and 47 cases of healthy volunteers enrolled in the study. Systolic cardiac function parameters were measured as ejection fraction(EF) , fractional shortening(FS) and mFS. Diastolic parameteres included peak early diastolic velocity (E) and late diastolic velocity (A) of mitral flow and their ratio (E/A), peak early diastolic velocity (Em) and late diastolic velocity (Am) of mitral annulus and their ratio (Em/Am). The correlation among these parameters was analyzed. Result:Left ventricular walls were thicker and mFS were lower in patient with hypertesion than those in control. The TDI parameters of left ventricular diastolic function such as Em and Em/Am were lower and E/Em was higher in hypertension group than in control. There were a positive correlation between mFS and Em/Am (r＝0.55,P<0.001). There was a negative correlation between mFS and E/Em(r=-0.38 P<0.01). Conclusion:mFS is a valuable parameter to assess systolic function in early stage of hypertension, which is associated with early stage of diastolic function damage.