CAJ | 학술논문

调节性T细胞是当前医学领域研究的热点之一.人类天然调节性T细胞是正常发生于胸腺的独特细胞系,对抑制自身免疫起重要作用.近年来发现其与肿瘤的发生密切相关.天然调节T细胞数量的增加、向肿瘤组织的游走和聚集及抑制免疫效应细胞的功能,是导致肿瘤细胞逃逸抗肿瘤免疫的重要机制,但其与肿瘤预后之间的关系仍不十分清楚,值得进一步研究,探讨更有效的药物作用靶点和新的治疗方法　.
조절성T세포시당전의학영역연구적열점지일.인류천연조절성T세포시정상발생우흉선적독특세포계,대억제자신면역기중요작용.근년래발현기여종류적발생밀절상관.천연조절T세포수량적증가、향종류조직적유주화취집급억제면역효응세포적공능,시도치종류세포도일항종류면역적중요궤제,단기여종류예후지간적관계잉불십분청초,치득진일보연구,탐토경유효적약물작용파점화신적치료방법　.
Regulatory T cells are a hotspot in medical domain nowadays.Human naturally occurring regulatory T cells(nTregs),derived from the thymus,play a critical role in the suppression of autoimmunity.Recent studies have suggested that there is a strong correlation between nTregs and tumor progression.The proliferation,aggregation,and transmigration towards tumor cells,of nTregs,all contribute to the escape of immune effector cells from antitumor immunity.However,the relationship between nTregs and prognosis of tumors is unclear.Further studies are required for the development of more effective drug targets and new therapy.