CAJ | 학술논문

目的研究尿铜蓝蛋白(CP)与糖尿病肾病(DN)的关系.方法将236例2型糖尿病患者分为正常白蛋白(Alb)尿组(DMN组)129例,微量Alb尿组(DMMA组)107例,另选择81例健康体检者作为对照组(C组).检测尿CP、Alb、肌酐(Cr)和血清CP等.结果 (1)尿CP/Cr中位数在DMMA组为2.55 ng/mmol,在DMN组为1.18 ng/mmol,均显著高于C组0.92 ng/mmol,P<0.01;血清CP在各组间比较差异均无统计学意义(P>0.05).(2)2型糖尿病患者尿Alb/Cr与尿CP/Cr呈显著正相关(r=0.188,P<0.01),糖尿病病程为尿CP/Cr和Alb/Cr升高的危险因素.结论 2型糖尿病患者尿CP与尿Alb排泄量有一致性升高的趋势.2型糖尿病患者尿CP升高,其与DN的发生和严重程度有较好的相关性,尿CP可以用来监测DN的发生、病情进展和治疗效果.
목적 연구뇨동람단백(CP)여당뇨병신병(DN)적관계.방법 장236례2형당뇨병환자분위정상백단백(Alb)뇨조(DMN조)129례,미량Alb뇨조(DMMA조)107례,령선택81례건강체검자작위대조조(C조).검측뇨CP、Alb、기항(Cr)화혈청CP등.결과 (1)뇨CP/Cr중위수재DMMA조위2.55 ng/mmol,재DMN조위1.18 ng/mmol,균현저고우C조0.92 ng/mmol,P<0.01;혈청CP재각조간비교차이균무통계학의의(P>0.05).(2)2형당뇨병환자뇨Alb/Cr여뇨CP/Cr정현저정상관(r=0.188,P<0.01),당뇨병병정위뇨CP/Cr화Alb/Cr승고적위험인소.결론 2형당뇨병환자뇨CP여뇨Alb배설량유일치성승고적추세.2형당뇨병환자뇨CP승고,기여DN적발생화엄중정도유교호적상관성,뇨CP가이용래감측DN적발생、병정진전화치료효과.
Objective To study the relationship between urinary ceruloplasmin(CP)and diabetic nephropathy. Methods Two hundred and thirty-six patients with type 2 diabetes mellitus were divided into normal albuminuria group(DMN group, 129 cases) and micro-albuminuria group ( DMMA group, 107 cases).Eighty-one healthy people were admitted into control group. The levels of urinary CP, serum CP, urinary albumin(Alb)and urinary creatinine(Cr)were measured. Results The median of urinary CP/Cr in DMMA group (2.55 ng/mmol) and DMN group (1.18 ng/mmol )was higher than that in control group(0.92 ng/mmol )(P<0.01 ). There was no significant difference in the levels of serum CP in each group (P>0.05 ).The urinary Alb/Cr was significantly positively correlated with urinary CP/Cr (r=0.188 ,P<0.01 )in patients with type 2 diabetes mellitus. The course of diabetes mellitus was a risk factor of urinary CP/Cr and Alb/Cr increase. Conclusions The urinary CP shows increasing tendency in accord with urinary Alb in type 2 diabetes mellitus patients. Urinary CP elevates obviously and correlates with diabetic nephropathy. Urinary CP may be used to monitor the onset, progress and therapeutic effect of diabetic nephropathy.