CAJ | 학술논문

目的通过分别检测急性冠状动脉综合征(ACS)患者、稳定型心绞痛(SAP)患者及对照者的血浆五聚素3(PTX3)水平及血清超敏C-反应蛋白(hs-CRP)水平,探讨血浆PTX3水平在各组间的差异以及血浆PTX3水平与ACS的相关性是否强于血清hs-CRP水平.方法入选经冠状动脉造影确诊为正常的20例患者为对照组;经冠状动脉造影确诊为冠心病58例,其中SAP 22例(SAP组),ACS 36例(ACS组).分别检测各组患者入院第2天的血浆PTX3、血清hs-CRP水平及各项常规血生化检查.血浆PTX3水平取对数后服从正态分布.应用SPSS 10.0统计软件对所得数据进行单因素方差分析和Logistic回归分析.结果ACS组患者的血浆PTX3对数水平高于SAP组和对照组,差异具有统计学意义(均P<0.05);SAP组与对照组之间差异无统计学意义(P>0.05).以组别为因变量,血浆PTX3对数水平和血清hs-CRP水平为协变量进行多分类变量Logistic回归分析显示血浆PTX3对数的参数估计值B=2.32(P<0.05),血清hs-CRP的估计值B=0.447(P>0.05).结论ACS患者血浆PTX3水平明显高于对照组和SAP组,主要表达于脉管系统的血浆PTX3与ACS的相关性优于血清hs-CRP.
목적 통과분별검측급성관상동맥종합정(ACS)환자、은정형심교통(SAP)환자급대조자적혈장오취소3(PTX3)수평급혈청초민C-반응단백(hs-CRP)수평,탐토혈장PTX3수평재각조간적차이이급혈장PTX3수평여ACS적상관성시부강우혈청hs-CRP수평.방법입선경관상동맥조영학진위정상적20례환자위대조조;경관상동맥조영학진위관심병58례,기중SAP 22례(SAP조),ACS 36례(ACS조).분별검측각조환자입원제2천적혈장PTX3、혈청hs-CRP수평급각항상규혈생화검사.혈장PTX3수평취대수후복종정태분포.응용SPSS 10.0통계연건대소득수거진행단인소방차분석화Logistic회귀분석.결과ACS조환자적혈장PTX3대수수평고우SAP조화대조조,차이구유통계학의의(균P<0.05);SAP조여대조조지간차이무통계학의의(P>0.05).이조별위인변량,혈장PTX3대수수평화혈청hs-CRP수평위협변량진행다분류변량Logistic회귀분석현시혈장PTX3대수적삼수고계치B=2.32(P<0.05),혈청hs-CRP적고계치B=0.447(P>0.05).결론ACS환자혈장PTX3수평명현고우대조조화SAP조,주요표체우맥관계통적혈장PTX3여ACS적상관성우우혈청hs-CRP.
Objective To explore the difference of plasma pentraxin 3 (PTX3) levels in acute coronary syndrome (ACS) patients,and to evaluate the correlation between plasma PTX3 levels and ACS as well as hypersensitive C-reaction protein (hs-CRP), through detecting the plasma levels of PTX3 and serum levels of hs-CRP in ACS patients, stable angina pectoris (SAP) patients and normal controls. Methods According to coronary angiography results,78 subjects were divided into control group (n = 20), stable angina pectoris (SAP) group (n = 22), and acute coronary syndrome (ACS) group (n = 36). The plasma levels of PTX3 and serum hs-CRP as well as routine blood biochemical markers were detected on the second day after admission. SPSS10.0 was used for one-factor analysis of variance and Logistic regression analysis. Results The logarithm level of plasma PTX3 in ACS group was significantly higher than that of the other two groups (P <0.05). The difference between the SAP group and the control group was not statistically significant (P > 0.05). Logistic regression analysis revealed that the estimated value of the plasma PTX3 logarithm level was 2.32 (P < 0.05), that of the serum hs-CRP was 0.447 (P > 0.05). Conclusion The plasma PTX3 level in ACS group is significantly higher than that of the SAP group and the control group. The correlation between plasma FTX3 levels and the ACS is stronger than that of the serum hs-CRP levels.