CAJ | 학술논문

细胞毒性T淋巴细胞(CTL)是机体抗肿瘤和抗病毒感染的关键效应细胞,CTL通过T细胞受体(TCR)特异识别靶细胞表面MHC-Ⅰ与抗原多肽形成的复合物,进而释放穿孔素、颗粒酶等生物活性物质对靶细胞进行溶解.鉴于CTL在治疗肿瘤和病毒性疾病中的潜在作用,对CTL的基础与应用研究备受关注,大多研究集中于对TCR基因的改造.随着分子生物学的发展,TCR基因克隆、转导技术已较成熟,研究方向主要是如何保证TCR基因高效、正确表达组装成为具生物活性的分子.
세포독성T림파세포(CTL)시궤체항종류화항병독감염적관건효응세포,CTL통과T세포수체(TCR)특이식별파세포표면MHC-Ⅰ여항원다태형성적복합물,진이석방천공소、과립매등생물활성물질대파세포진행용해.감우CTL재치료종류화병독성질병중적잠재작용,대CTL적기출여응용연구비수관주,대다연구집중우대TCR기인적개조.수착분자생물학적발전,TCR기인극륭、전도기술이교성숙,연구방향주요시여하보증TCR기인고효、정학표체조장성위구생물활성적분자.
Cytotoxic T lymphocytes (CTLs) are critical effectors which play important roles both in anti-tumor and anti-virus immune responses.Through T cell receptors(TCRs),CTLs can specifically recognize MHC- Ⅰ -peptides complexes presented on the surface of target cells,and then release biological substances such as perforin and granzymes into the target cells and dissolve them.Since the significant potential value of CTLs,more and more people are focusing on its basic and appliedstudies.Most researches are about the transformation of the TCR gene.With the development of molecular biology,cloning and transduction of TCR gene have been more mature.Researchers are finding ways to ensure that TCR gene expresses efficiently and assemble correctly.