CAJ | 학술논문

神经生长因子是一种对在神经细胞生长、分化中起营养作用的神经肽类,是神经营养因子家族中的一员.它由神经细胞、炎症细胞及气道上皮细胞分泌产生,在支气管哮喘气道炎症、气道重塑等病理过程中发挥重要作用.研究显示其通过介导免疫失衡,分泌神经肽,启动肾上腺髓质细胞冗余性和气道重塑等而参与支气管哮喘的发生、发展.深入了解神经牛长因子在支气管哮喘中的作用,有助于形成新的支气管哮喘防治策略.
신경생장인자시일충대재신경세포생장、분화중기영양작용적신경태류,시신경영양인자가족중적일원.타유신경세포、염증세포급기도상피세포분비산생,재지기관효천기도염증、기도중소등병리과정중발휘중요작용.연구현시기통과개도면역실형,분비신경태,계동신상선수질세포용여성화기도중소등이삼여지기관효천적발생、발전.심입료해신경우장인자재지기관효천중적작용,유조우형성신적지기관효천방치책략.
Nerve growth factor is a kind of neuropeptide which plays a role of nutrition in neurons growth and differentiation,and a family of neurotrophic factor.It is secreted by neurons,inflammatory cells and airway epithelial cells and plays a critical role in airway inflammatory and remodeling.Research showed that nerve growth factor exerts its role in asthmatic occurrence and development through immune imbalance,secreting neuropeptide,starting the redundancy of adrenal medulla cells and airway remodeling.Further investigation is needed to figure out its role in asthma,which may be helpful to build new strategies to prevent asthma.