CAJ | 학술논문

肝细胞生长因子(HGF)是一个多功能的细胞因子,作用于细胞表面的跨膜受体c-Met发挥生物学作用.许多肿瘤的生长、侵袭和转移都与HGF-c-Met信号转导通路异常有关.HGF及其受体c-Met与多发性骨髓瘤(MM)的发生、转移、侵袭及预后关系密切.
간세포생장인자(HGF)시일개다공능적세포인자,작용우세포표면적과막수체c-Met발휘생물학작용.허다종류적생장、침습화전이도여HGF-c-Met신호전도통로이상유관.HGF급기수체c-Met여다발성골수류(MM)적발생、전이、침습급예후관계밀절.
Hepatocyte growth factor ( HGF),a multifunctional cytokine,plays a biological role through acting on the cell surface transmembrane receptor c-Met.The growth,invasion and metastasis of many tumors are associated with the abnormalities of HGF-c-Met signaling pathway.Studies found that HGF and its receptor c-Met have close relations with the occurrence,metastasis,invasion and prognosis of multiple myeloma.