CAJ | 학술논문

目的探讨肝细胞肝癌(HCC)患者血清甲胎蛋白-IgM免疫复合物(AFP-IgM)的表达水平及其临床意义.方法应用酶联免疫吸附分析(ELISA)法检测79例HCC患者、20例中度肝硬化患者和30例健康对照者血清中AFP-IgM水平,并进行对比分析.结果 AFP-IgM的浓度和阳性率分别为HCC组422.20×103AU/L和73%,肝硬化组268.85×103AU/L和20%,健康对照组119.71×103AU/L1和7%.HCC组阳性率显著高于肝硬化组和健康对照组(分别P＜0.01);Ⅰ期和Ⅱ期HCC AFP-IgM阳性率(分别为89%和88%)高于Ⅲ期(30%,P＜0.05);AFP-IgM的水平与肿瘤分期、大小有关.结论血清AFP-IgM对HCC的早期诊断具有重要意义,有望成为一个有用的辅助诊断HCC的生物标志.
목적 탐토간세포간암(HCC)환자혈청갑태단백-IgM면역복합물(AFP-IgM)적표체수평급기림상의의.방법 응용매련면역흡부분석(ELISA)법검측79례HCC환자、20례중도간경화환자화30례건강대조자혈청중AFP-IgM수평,병진행대비분석.결과 AFP-IgM적농도화양성솔분별위HCC조422.20×103AU/L화73%,간경화조268.85×103AU/L화20%,건강대조조119.71×103AU/L1화7%.HCC조양성솔현저고우간경화조화건강대조조(분별P＜0.01);Ⅰ기화Ⅱ기HCC AFP-IgM양성솔(분별위89%화88%)고우Ⅲ기(30%,P＜0.05);AFP-IgM적수평여종류분기、대소유관.결론 혈청AFP-IgM대HCC적조기진단구유중요의의,유망성위일개유용적보조진단HCC적생물표지.
Objective To investigate the expression level of AFP-IgM in hepatocellular carcinoma (HCC).Methods The serum AFP-IgM concentrations were detected by ELISA in 79 HCC patients,20 patients affected by liver cirrhosis and 30 healthy controls.Results AFP-IgM concentrations in serum and the positive rate were significantly higher in HCC than that in liver cirrhosis and in healthy controls(P＜0.01).The positive rates of AFP-IgM in the stage Ⅰ or Ⅱ(89%,88%)were higher than that of the stage Ⅲ(30%,P＜0.05).The serum concentration of AFP-IgM is related to the stage,tumor sizes.Conclusion AFP-IgM was of significance for early diagnosis of HCC,it will hopefully be a useful biological marker for the diagnosis of HCC.