CAJ | 학술논문

目的探讨女性系统性红斑狼疮合并肺动脉高压患者的西地那非联合辛伐他汀治疗的疗效.方法 26名女性系统性红斑狼疮合并肺动脉高压患者分为单药治疗组和联合治疗组各13例.前者急性血管反应性试验阳性者11例,阴性者2例,11例予氨氯地平片2.5 mg 1次/d,一周后加量至5 mg1次/d.2例予雷米普剂片2.5 mg,1次/d,1周后加量至5 mg,1次/d.后者予西地那非片50 mg,3次/d及辛伐地汀80 mg,1次/d,两组疗程均为3个月.试验前后进行生活质量问卷评分(QOL),并测量右室收缩压,(RVSP)及6 min步行距离(6-MWT).结果两组患者治疗后QOL,RVSP及6-MWT均较治疗前有明显改善,与单药治疗组相比,联合治疗组各指标改善更为显著.结论西地那非联合辛伐他汀治疗女性系统性红斑狼疮和并肺动脉高压患者疗效较好.比单药治疗组能更有效地降低肺动脉压,改善生活质镀,提高运动耐力.
목적 탐토녀성계통성홍반랑창합병폐동맥고압환자적서지나비연합신벌타정치료적료효.방법 26명녀성계통성홍반랑창합병폐동맥고압환자분위단약치료조화연합치료조각13례.전자급성혈관반응성시험양성자11례,음성자2례,11례여안록지평편2.5 mg 1차/d,일주후가량지5 mg1차/d.2례여뢰미보제편2.5 mg,1차/d,1주후가량지5 mg,1차/d.후자여서지나비편50 mg,3차/d급신벌지정80 mg,1차/d,량조료정균위3개월.시험전후진행생활질량문권평분(QOL),병측량우실수축압,(RVSP)급6 min보행거리(6-MWT).결과 량조환자치료후QOL,RVSP급6-MWT균교치료전유명현개선,여단약치료조상비,연합치료조각지표개선경위현저.결론 서지나비연합신벌타정치료녀성계통성홍반랑창화병폐동맥고압환자료효교호.비단약치료조능경유효지강저폐동맥압,개선생활질도,제고운동내력.
Objective Investigate the clinic efficacy of combination use of Sildenafil and Simvastatin on pulmonary hypertension in female patients with SLE.Methods 26 female SLE patients with PH were randomly divided into solo-medication group(n=13) and combined-medication group(n=13).In the former group,there are 11 patients positive in acute artery reaction test and 2 negative,11 positive patients received Amlodipine 2.5 mg qd,then 5 mg qd a week later;2 negative patients received Ramipril 2.5 mg qd,then 5 mg qd a week later.The latter group received Sildenafil 50 mg tid and Simvastatin 80 mg qd.The treatment duration is 3 months.The change of Quality of Life(QOL)、RVSP、6-MWT were measured after drugs were given.Results QOL、RVSP and 6-MWT were all effectively improved in both groups after treatment.Compared with solomedication group,the change of QOL、RVSP and 6-MWT was much more signifieandy.Conclusion Combination use of Sildenafil and Simvastatin could alleviate PH,improved quality of life and exercise tolerance more offectively compared with traditional treatment.