CAJ | 학술논문

目的比较来氟米特(LEF)和环磷酰胺(CTX)治疗狼疮肾炎(LN)的疗效、不良反应及安全性。方法 43例活动性LN患者在使用激素的基础上随机分为两组，LEF组22例和CTX组21例，LEF组给予LEF 20 mg/d，半年为一疗程；CTX组间断给予CTX 12 mg·kg-1·d-2加入10％葡萄糖注射液250 ml中静脉滴注，每2周为一疗程，环磷酰胺总累计量控制在150 mg/kg以内，随访6个月，监测血常规、血清白蛋白(Alb)、血肌酐(SCr)、ANA、ds-DNA、血24h尿蛋白定量、尿沉渣红细胞计数和白细胞计数和可能伴随的不良反应。结果治疗总有效率LEF组81.8％，CTX组85.7％，组间差异无统计学意义。不良反应CTX组13例(61.9％)，LEF组3例(13.6％)，组间差异有统计学意义。结论 LEF治疗LN疗效与CTX相当，但其不良反应相对较轻，耐受性较好。
목적 비교래불미특(LEF)화배린선알(CTX)치료랑창신염(LN)적료효、불량반응급안전성。방법 43례활동성LN환자재사용격소적기출상수궤분위량조，LEF조22례화CTX조21례，LEF조급여LEF 20 mg/d，반년위일료정；CTX조간단급여CTX 12 mg·kg-1·d-2가입10％포도당주사액250 ml중정맥적주，매2주위일료정，배린선알총루계량공제재150 mg/kg이내，수방6개월，감측혈상규、혈청백단백(Alb)、혈기항(SCr)、ANA、ds-DNA、혈24h뇨단백정량、뇨침사홍세포계수화백세포계수화가능반수적불량반응。결과 치료총유효솔LEF조81.8％，CTX조85.7％，조간차이무통계학의의。불량반응CTX조13례(61.9％)，LEF조3례(13.6％)，조간차이유통계학의의。결론 LEF치료LN료효여CTX상당，단기불량반응상대교경，내수성교호。
Objective To compare the therapeutic effect, adverse effects and safety of leflunomide (LEF)and cyclophosphamide(CTX) on lupus nephritis(LN). Methods 43 patients with reactive LN were randomly divided into two groups. Based on hormone application,22 cases in LEF group were given LEF orally and 21 cases in CTX group were given CTX intravenous drip discontinuously. They were followed up for six months. The related indexes and possible concomitant adverse effects were detected. Results The total effective rate in LEF group was 81.8％ and that in CTX group was 85.7％. The tolerance in LEF group was better and 3 cases had adverse effects. 13 cases in CTX group had adverse effects. Conclusion LEF had the same efficacy as CTX in the LN therapy, but the tolerance is better and the side effects are minor than CTX.