中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2010年
3期
221-224
,共4页
池琼%郑纪阳%戴新建%郑永克%陈身贤%徐海苗%黄晓萍
池瓊%鄭紀暘%戴新建%鄭永剋%陳身賢%徐海苗%黃曉萍
지경%정기양%대신건%정영극%진신현%서해묘%황효평
肺肿瘤%膜式超薄液基细胞学检测技术%直接涂片法%纤维支气管镜刷片%支气管肺泡灌洗液
肺腫瘤%膜式超薄液基細胞學檢測技術%直接塗片法%纖維支氣管鏡刷片%支氣管肺泡灌洗液
폐종류%막식초박액기세포학검측기술%직접도편법%섬유지기관경쇄편%지기관폐포관세액
Lung neoplasms%ThinPrep cytology test%Direct smear%Bronchial brushing cytology%Bronchoalveolar lavage fluid
目的 探讨膜式超薄液基细胞学检测技术(TCT)在肺癌诊断中的应用价值.方法 收集143例肺癌患者和139例非肺癌患者的支气管肺泡灌洗液(BALF)和(或)纤维支气管镜刷片标本353个,同时进行TCT和直接涂片法检测,比较两种方法的敏感度和特异度.结果 TCT检测的敏感度为39.6%,特异度为99.4%,直接涂片法检测的敏感度为8.3%,特异度为100%,TCT检测的敏感度高于直接涂片法(P<0.01),特异度差异无统计学意义(P>0.05).BALF的TCT检测敏感度为41.5%,特异度为100%;直接涂片法诊断的敏感度为5.2%,特异度为100%.纤维支气管镜刷片的TCT检测敏感度为35.1%,特异度为96.4%;直接涂片法诊断的敏感度为15.8%,特异度为100%.与直接涂片法比较,两种标本的TCT检测敏感度较高(P<0.01),特异度差异无统计学意义(P>0.05).71例同时采集BALF和纤维支气管镜刷片患者,BALF TCT检测的敏感度(49.0%)高于纤维支气管镜刷片TCT检测的敏感度(32.7%,P<0.05).肺癌患者中,同时有TCT分类诊断和病理组织学诊断结果的标本有69个,TCT分类诊断和病理组织学诊断的总符合率为84.1%.结论 TCT检测能提高肺癌的诊断率,BALF的TCT检测可推广应用于临床.
目的 探討膜式超薄液基細胞學檢測技術(TCT)在肺癌診斷中的應用價值.方法 收集143例肺癌患者和139例非肺癌患者的支氣管肺泡灌洗液(BALF)和(或)纖維支氣管鏡刷片標本353箇,同時進行TCT和直接塗片法檢測,比較兩種方法的敏感度和特異度.結果 TCT檢測的敏感度為39.6%,特異度為99.4%,直接塗片法檢測的敏感度為8.3%,特異度為100%,TCT檢測的敏感度高于直接塗片法(P<0.01),特異度差異無統計學意義(P>0.05).BALF的TCT檢測敏感度為41.5%,特異度為100%;直接塗片法診斷的敏感度為5.2%,特異度為100%.纖維支氣管鏡刷片的TCT檢測敏感度為35.1%,特異度為96.4%;直接塗片法診斷的敏感度為15.8%,特異度為100%.與直接塗片法比較,兩種標本的TCT檢測敏感度較高(P<0.01),特異度差異無統計學意義(P>0.05).71例同時採集BALF和纖維支氣管鏡刷片患者,BALF TCT檢測的敏感度(49.0%)高于纖維支氣管鏡刷片TCT檢測的敏感度(32.7%,P<0.05).肺癌患者中,同時有TCT分類診斷和病理組織學診斷結果的標本有69箇,TCT分類診斷和病理組織學診斷的總符閤率為84.1%.結論 TCT檢測能提高肺癌的診斷率,BALF的TCT檢測可推廣應用于臨床.
목적 탐토막식초박액기세포학검측기술(TCT)재폐암진단중적응용개치.방법 수집143례폐암환자화139례비폐암환자적지기관폐포관세액(BALF)화(혹)섬유지기관경쇄편표본353개,동시진행TCT화직접도편법검측,비교량충방법적민감도화특이도.결과 TCT검측적민감도위39.6%,특이도위99.4%,직접도편법검측적민감도위8.3%,특이도위100%,TCT검측적민감도고우직접도편법(P<0.01),특이도차이무통계학의의(P>0.05).BALF적TCT검측민감도위41.5%,특이도위100%;직접도편법진단적민감도위5.2%,특이도위100%.섬유지기관경쇄편적TCT검측민감도위35.1%,특이도위96.4%;직접도편법진단적민감도위15.8%,특이도위100%.여직접도편법비교,량충표본적TCT검측민감도교고(P<0.01),특이도차이무통계학의의(P>0.05).71례동시채집BALF화섬유지기관경쇄편환자,BALF TCT검측적민감도(49.0%)고우섬유지기관경쇄편TCT검측적민감도(32.7%,P<0.05).폐암환자중,동시유TCT분류진단화병리조직학진단결과적표본유69개,TCT분류진단화병리조직학진단적총부합솔위84.1%.결론 TCT검측능제고폐암적진단솔,BALF적TCT검측가추엄응용우림상.
Objective To explore the diagnostic value of ThinPrep cytology test(TCT)in lung cancer.Methods 353 cases of bronchoalveolar lavage fluid(BALF)and(or)bronchial brushing cytology (192 cases from lung cancer patiets and 16l cases from benign lung disease patients)were detected with TCT and method of direct smeat.respectively.The sensitivity and specificity of two methods was compared.Results The sensitivity and specificity of TCT were 39.6% and 99.4%.And which of direct smear method were 8.3% and 100%.respectively.The sensitivity of TCT wits significantly higher than that of method of direct smeat in the diagnosis of lung cancer(P<0.01).There were 71 patients who underwent BALF and bronchial brushing cytology simultaneously,the sensitivity of TCT of BALF was higher than that of bronchial brushing cytology(P<0.05) of the 69 cases which had both TCT and histopathological results,TCT and pathology concordance rate was 84.1%.Conclusion TCT has more diagnostic value in lung cancer:BALF is more preponderant than bronchial brushing cytology by TCT in the diagnosis of lung cancer.
